So different, yet so similar: meta-analysis and policy modeling of willingness to participate in clinical trials among Brazilians and Indians.
Abstract
BACKGROUND: With the global expansion of clinical trials and the expectations of the
rise of the emerging economies known as BRICs (Brazil, Russia, India and China), the
understanding of factors that affect the willingness to participate in clinical trials
of patients from those countries assumes a central role in the future of health research.
METHODS: We conducted a systematic review and meta-analysis (SRMA) of willingness
to participate in clinical trials among Brazilian patients and then we compared it
with Indian patients (with results of another SRMA previously conducted by our group)
through a system dynamics model. RESULTS: Five studies were included in the SRMA of
Brazilian patients. Our main findings are 1) the major motivation for Brazilian patients
to participate in clinical trials is altruism, 2) monetary reimbursement is the least
important factor motivating Brazilian patients, 3) the major barrier for Brazilian
patients to not participate in clinical trials is the fear of side effects, and 4)
Brazilian patients are more likely willing to participate in clinical trials than
Indians. CONCLUSION: Our study provides important insights for investigators and sponsors
for planning trials in Brazil (and India) in the future. Ignoring these results may
lead to unnecessary fund/time spending. More studies are needed to validate our results
and for better understanding of this poorly studied theme.
Type
Journal articleSubject
Acquired Immunodeficiency SyndromeAdolescent
Adult
Altruism
Brazil
Clinical Trials as Topic
Cultural Characteristics
Female
HIV Infections
Humans
India
Male
Middle Aged
Motivation
Patient Participation
Patient Selection
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https://hdl.handle.net/10161/4586Published Version (Please cite this version)
10.1371/journal.pone.0014368Publication Info
Zammar, Guilherme; Meister, Henrique; Shah, Jatin; Phadtare, Amruta; Cofiel, Luciana;
& Pietrobon, Ricardo (2010). So different, yet so similar: meta-analysis and policy modeling of willingness to
participate in clinical trials among Brazilians and Indians. PLoS One, 5(12). pp. e14368. 10.1371/journal.pone.0014368. Retrieved from https://hdl.handle.net/10161/4586.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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