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So different, yet so similar: meta-analysis and policy modeling of willingness to participate in clinical trials among Brazilians and Indians.

dc.contributor.author Cofiel, L
dc.contributor.author Meister, H
dc.contributor.author Phadtare, Amruta
dc.contributor.author Pietrobon, Ricardo Santos
dc.contributor.author Shah, J
dc.contributor.author Zammar, G
dc.coverage.spatial United States
dc.date.accessioned 2011-06-21T17:32:20Z
dc.date.issued 2010-12-16
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/21179556
dc.identifier.uri https://hdl.handle.net/10161/4586
dc.description.abstract BACKGROUND: With the global expansion of clinical trials and the expectations of the rise of the emerging economies known as BRICs (Brazil, Russia, India and China), the understanding of factors that affect the willingness to participate in clinical trials of patients from those countries assumes a central role in the future of health research. METHODS: We conducted a systematic review and meta-analysis (SRMA) of willingness to participate in clinical trials among Brazilian patients and then we compared it with Indian patients (with results of another SRMA previously conducted by our group) through a system dynamics model. RESULTS: Five studies were included in the SRMA of Brazilian patients. Our main findings are 1) the major motivation for Brazilian patients to participate in clinical trials is altruism, 2) monetary reimbursement is the least important factor motivating Brazilian patients, 3) the major barrier for Brazilian patients to not participate in clinical trials is the fear of side effects, and 4) Brazilian patients are more likely willing to participate in clinical trials than Indians. CONCLUSION: Our study provides important insights for investigators and sponsors for planning trials in Brazil (and India) in the future. Ignoring these results may lead to unnecessary fund/time spending. More studies are needed to validate our results and for better understanding of this poorly studied theme.
dc.language eng
dc.language.iso en_US
dc.relation.ispartof PLoS One
dc.relation.isversionof 10.1371/journal.pone.0014368
dc.subject Acquired Immunodeficiency Syndrome
dc.subject Adolescent
dc.subject Adult
dc.subject Altruism
dc.subject Brazil
dc.subject Clinical Trials as Topic
dc.subject Cultural Characteristics
dc.subject Female
dc.subject HIV Infections
dc.subject Humans
dc.subject India
dc.subject Male
dc.subject Middle Aged
dc.subject Motivation
dc.subject Patient Participation
dc.subject Patient Selection
dc.title So different, yet so similar: meta-analysis and policy modeling of willingness to participate in clinical trials among Brazilians and Indians.
dc.title.alternative
dc.type Journal article
dc.description.version Version of Record
duke.date.pubdate 2010-12-16
duke.description.issue 12
duke.description.volume 5
dc.relation.journal Plos One
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/21179556
pubs.begin-page e14368
pubs.issue 12
pubs.organisational-group Duke
pubs.organisational-group Faculty
pubs.publication-status Published online
pubs.volume 5
dc.identifier.eissn 1932-6203


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