Show simple item record Heinzen, EL Need, AC Hayden, KM Chiba-Falek, O Roses, AD Strittmatter, WJ Burke, JR Hulette, CM Welsh-Bohmer, KA Goldstein, DB
dc.coverage.spatial Netherlands 2011-06-21T17:32:24Z 2010
dc.identifier V7N8Q30275184532
dc.identifier.citation J Alzheimers Dis, 2010, 19 (1), pp. 69 - 77
dc.description.abstract Alzheimer's disease is a complex and progressive neurodegenerative disease leading to loss of memory, cognitive impairment, and ultimately death. To date, six large-scale genome-wide association studies have been conducted to identify SNPs that influence disease predisposition. These studies have confirmed the well-known APOE epsilon4 risk allele, identified a novel variant that influences disease risk within the APOE epsilon4 population, found a SNP that modifies the age of disease onset, as well as reported the first sex-linked susceptibility variant. Here we report a genome-wide scan of Alzheimer's disease in a set of 331 cases and 368 controls, extending analyses for the first time to include assessments of copy number variation. In this analysis, no new SNPs show genome-wide significance. We also screened for effects of copy number variation, and while nothing was significant, a duplication in CHRNA7 appears interesting enough to warrant further investigation.
dc.format.extent 69 - 77
dc.language eng
dc.language.iso en_US en_US
dc.relation.ispartof J Alzheimers Dis
dc.relation.isversionof 10.3233/JAD-2010-1212
dc.subject Adult
dc.subject Aged
dc.subject Aged, 80 and over
dc.subject Alzheimer Disease
dc.subject Apolipoprotein E4
dc.subject DNA Copy Number Variations
dc.subject Female
dc.subject Genetic Predisposition to Disease
dc.subject Genetic Variation
dc.subject Genome-Wide Association Study
dc.subject Humans
dc.subject Male
dc.subject Middle Aged
dc.subject Polymorphism, Single Nucleotide
dc.subject Young Adult
dc.title Genome-wide scan of copy number variation in late-onset Alzheimer's disease.
dc.title.alternative en_US
dc.type Journal Article
dc.description.version Version of Record en_US 2010-00-00 en_US
duke.description.endpage 77 en_US
duke.description.issue 1 en_US
duke.description.startpage 69 en_US
duke.description.volume 19 en_US
dc.relation.journal Journal of Alzheimers Disease en_US
pubs.issue 1
pubs.organisational-group /Duke
pubs.organisational-group /Duke/Faculty
pubs.organisational-group /Duke/Institutes and Provost's Academic Units
pubs.organisational-group /Duke/Institutes and Provost's Academic Units/University Institutes and Centers
pubs.organisational-group /Duke/Institutes and Provost's Academic Units/University Institutes and Centers/Duke Institute for Brain Sciences
pubs.organisational-group /Duke/School of Medicine
pubs.organisational-group /Duke/School of Medicine/Basic Science Departments
pubs.organisational-group /Duke/School of Medicine/Basic Science Departments/Molecular Genetics and Microbiology
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Neurology
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Neurology/Neurology, Behavioral Neurology
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Pathology
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Psychiatry & Behavioral Sciences
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Psychiatry & Behavioral Sciences/Psychiatry & Behavioral Sciences, Geriatric Behavioral Health
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers/Duke Center for Human Genome Variation
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers/Duke Clinical Research Institute
pubs.organisational-group /Duke/Trinity College of Arts & Sciences
pubs.organisational-group /Duke/Trinity College of Arts & Sciences/Psychology and Neuroscience
pubs.publication-status Published
pubs.volume 19
dc.identifier.eissn 1875-8908

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