Effects of neuronal PIK3C3/Vps34 deletion on autophagy and beyond.
Abstract
PIK3C3/Vps34 plays important roles in the endocytic and autophagic pathways, both
of which are essential for maintaining neuronal integrity. However, it is unclear
how inactivating PIK3C3 may affect neuronal endosomal versus autophagic processes
in vivo. We generated a conditional null allele of the Pik3c3 gene in mouse, and specifically
deleted it in postmitotic sensory neurons. Subsequent analyses reveal several interesting
and surprising findings.
Type
Journal articleSubject
AnimalsAutophagy
Cell Membrane
Enzyme Activation
Gene Deletion
Membrane Proteins
Mice
Mice, Knockout
Phagosomes
Phenotype
Phosphatidylinositol 3-Kinase
Phosphatidylinositol Phosphates
Sensory Receptor Cells
Permalink
https://hdl.handle.net/10161/4636Collections
More Info
Show full item recordScholars@Duke
Fan Wang
Adjunct Professor in the Department of Neurobiology
My lab studies neural circuit basis of sensory perception. Specifically we are interested
in determining neural circuits underlying (1) active touch sensation including tactile
processing stream and motor control of touch sensors on the face; (2) pain sensation
including both sensory-discriminative and affective aspects of pain; and (3) general
anesthesia including the active pain-suppression process. We use a combination of
genetic, viral, electrophysiology, and in vivo imaging (in f
Articles written by Duke faculty are made available through the campus open access policy. For more information see: Duke Open Access Policy
Rights for Collection: Scholarly Articles
Works are deposited here by their authors, and represent their research and opinions, not that of Duke University. Some materials and descriptions may include offensive content. More info