Show simple item record Zhou, X Wang, F
dc.coverage.spatial United States 2011-06-21T20:18:52Z 2010-08
dc.identifier 12511
dc.identifier.citation Autophagy, 2010, 6 (6), pp. 798 - 799
dc.description.abstract PIK3C3/Vps34 plays important roles in the endocytic and autophagic pathways, both of which are essential for maintaining neuronal integrity. However, it is unclear how inactivating PIK3C3 may affect neuronal endosomal versus autophagic processes in vivo. We generated a conditional null allele of the Pik3c3 gene in mouse, and specifically deleted it in postmitotic sensory neurons. Subsequent analyses reveal several interesting and surprising findings.
dc.format.extent 798 - 799
dc.language eng
dc.language.iso en_US en_US
dc.relation.ispartof Autophagy
dc.subject Animals
dc.subject Autophagy
dc.subject Cell Membrane
dc.subject Enzyme Activation
dc.subject Gene Deletion
dc.subject Membrane Proteins
dc.subject Mice
dc.subject Mice, Knockout
dc.subject Phagosomes
dc.subject Phenotype
dc.subject Phosphatidylinositol 3-Kinase
dc.subject Phosphatidylinositol Phosphates
dc.subject Sensory Receptor Cells
dc.title Effects of neuronal PIK3C3/Vps34 deletion on autophagy and beyond.
dc.title.alternative en_US
dc.type Journal Article
dc.description.version Version of Record en_US 2010-8-16 en_US
duke.description.endpage 799 en_US
duke.description.issue 6 en_US
duke.description.startpage 798 en_US
duke.description.volume 6 en_US
dc.relation.journal Autophagy en_US
pubs.issue 6
pubs.organisational-group /Duke
pubs.organisational-group /Duke/Institutes and Provost's Academic Units
pubs.organisational-group /Duke/Institutes and Provost's Academic Units/University Institutes and Centers
pubs.organisational-group /Duke/Institutes and Provost's Academic Units/University Institutes and Centers/Duke Institute for Brain Sciences
pubs.organisational-group /Duke/School of Medicine
pubs.organisational-group /Duke/School of Medicine/Basic Science Departments
pubs.organisational-group /Duke/School of Medicine/Basic Science Departments/Cell Biology
pubs.organisational-group /Duke/School of Medicine/Basic Science Departments/Neurobiology
pubs.publication-status Published
pubs.volume 6
dc.identifier.eissn 1554-8635

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