Refractive changes after descemet stripping endothelial keratoplasty: a simplified mathematical model.
Abstract
PURPOSE: To develop a mathematical model that can predict refractive changes after
Descemet stripping endothelial keratoplasty (DSEK). METHODS: A mathematical formula
based on the Gullstrand eye model was generated to estimate the change in refractive
power of the eye after DSEK. This model was applied to four DSEK cases retrospectively,
to compare measured and predicted refractive changes after DSEK. RESULTS: The refractive
change after DSEK is determined by calculating the difference in the power of the
eye before and after DSEK surgery. The power of the eye post-DSEK surgery can be calculated
with modified Gullstrand eye model equations that incorporate the change in the posterior
radius of curvature and change in the distance between the principal planes of the
cornea and lens after DSEK. Analysis of this model suggests that the ratio of central
to peripheral graft thickness (CP ratio) and central thickness can have significant
effect on refractive change where smaller CP ratios and larger graft thicknesses result
in larger hyperopic shifts. This model was applied to four patients, and the average
predicted hyperopic shift in the overall power of the eye was calculated to be 0.83
D. This change reflected in a mean of 93% (range, 75%-110%) of patients' measured
refractive shifts. CONCLUSIONS: This simplified DSEK mathematical model can be used
as a first step for estimating the hyperopic shift after DSEK. Further studies are
necessary to refine the validity of this model.
Type
Journal articleSubject
CorneaDescemet Stripping Endothelial Keratoplasty
Fuchs' Endothelial Dystrophy
Humans
Hyperopia
Models, Theoretical
Refraction, Ocular
Retrospective Studies
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https://hdl.handle.net/10161/5106Published Version (Please cite this version)
10.1167/iovs.10-5839Publication Info
Hwang, Richard Y; Gauthier, Daniel J; Wallace, Dana; & Afshari, Natalie A (2011). Refractive changes after descemet stripping endothelial keratoplasty: a simplified
mathematical model. Invest Ophthalmol Vis Sci, 52(2). pp. 1043-1054. 10.1167/iovs.10-5839. Retrieved from https://hdl.handle.net/10161/5106.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
Daniel J. Gauthier
Research Professor of Physics
Prof. Gauthier is interested in a broad range of topics in the fields of nonlinear
and quantum optics, and nonlinear dynamical systems.
In the area of optical physics, his group is studying the fundamental characteristics
of highly nonlinear light-matter interactions at both the classical and quantum levels
and is using this understanding to develop practical devices.
At the quantum level, his group has three major efforts in the area of quantum communication
and networking. I

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