Regulation of G protein-coupled receptor signaling by scaffold proteins.
Abstract
The actions of many hormones and neurotransmitters are mediated through stimulation
of G protein-coupled receptors. A primary mechanism by which these receptors exert
effects inside the cell is by association with heterotrimeric G proteins, which can
activate a wide variety of cellular enzymes and ion channels. G protein-coupled receptors
can also interact with a number of cytoplasmic scaffold proteins, which can link the
receptors to various signaling intermediates and intracellular effectors. The multicomponent
nature of G protein-coupled receptor signaling pathways makes them ideally suited
for regulation by scaffold proteins. This review focuses on several specific examples
of G protein-coupled receptor-associated scaffolds and the roles they may play in
organizing receptor-initiated signaling pathways in the cardiovascular system and
other tissues.
Type
Journal articleSubject
AnimalsArrestins
Heterotrimeric GTP-Binding Proteins
Macromolecular Substances
Models, Biological
Myocardium
Proteins
Receptors, Adrenergic
Receptors, Cell Surface
Signal Transduction
beta-Arrestins
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Robert J. Lefkowitz
The Chancellor's Distinguished Professor of Medicine
Dr. Lefkowitz’s memoir, A Funny Thing Happened on the Way to Stockholm, recounts his
early career as a cardiologist and his transition to biochemistry, which led to his
Nobel Prize win.
Robert J. Lefkowitz, M.D. is James B. Duke Professor of Medicine and Professor of
Biochemistry and Chemistry at the Duke University Medical Center. He has been an Investigator
of the

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