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Regulation of G protein-coupled receptor signaling by scaffold proteins.

dc.contributor.author Hall, Randy A
dc.contributor.author Lefkowitz, Robert J
dc.coverage.spatial United States
dc.date.accessioned 2012-10-23T22:04:16Z
dc.date.issued 2002-10-18
dc.identifier https://www.ncbi.nlm.nih.gov/pubmed/12386143
dc.identifier.uri https://hdl.handle.net/10161/5917
dc.description.abstract The actions of many hormones and neurotransmitters are mediated through stimulation of G protein-coupled receptors. A primary mechanism by which these receptors exert effects inside the cell is by association with heterotrimeric G proteins, which can activate a wide variety of cellular enzymes and ion channels. G protein-coupled receptors can also interact with a number of cytoplasmic scaffold proteins, which can link the receptors to various signaling intermediates and intracellular effectors. The multicomponent nature of G protein-coupled receptor signaling pathways makes them ideally suited for regulation by scaffold proteins. This review focuses on several specific examples of G protein-coupled receptor-associated scaffolds and the roles they may play in organizing receptor-initiated signaling pathways in the cardiovascular system and other tissues.
dc.language eng
dc.publisher Ovid Technologies (Wolters Kluwer Health)
dc.relation.ispartof Circ Res
dc.subject Animals
dc.subject Arrestins
dc.subject Heterotrimeric GTP-Binding Proteins
dc.subject Macromolecular Substances
dc.subject Models, Biological
dc.subject Myocardium
dc.subject Proteins
dc.subject Receptors, Adrenergic
dc.subject Receptors, Cell Surface
dc.subject Signal Transduction
dc.subject beta-Arrestins
dc.title Regulation of G protein-coupled receptor signaling by scaffold proteins.
dc.type Journal article
duke.contributor.id Lefkowitz, Robert J|0096962
duke.description.issue 8
duke.description.volume 91
dc.relation.journal Circulation Research
pubs.author-url https://www.ncbi.nlm.nih.gov/pubmed/12386143
pubs.begin-page 672
pubs.end-page 680
pubs.issue 8
pubs.organisational-group Basic Science Departments
pubs.organisational-group Biochemistry
pubs.organisational-group Chemistry
pubs.organisational-group Clinical Science Departments
pubs.organisational-group Duke
pubs.organisational-group Duke Cancer Institute
pubs.organisational-group Institutes and Centers
pubs.organisational-group Medicine
pubs.organisational-group Medicine, Cardiology
pubs.organisational-group Pathology
pubs.organisational-group School of Medicine
pubs.organisational-group Trinity College of Arts & Sciences
pubs.publication-status Published
pubs.volume 91
dc.identifier.eissn 1524-4571


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