Show simple item record Arriza, JL Dawson, TM Simerly, RB Martin, LJ Caron, MG Snyder, SH Lefkowitz, RJ
dc.coverage.spatial United States 2012-10-23T22:17:17Z 1992-10
dc.identifier.citation J Neurosci, 1992, 12 (10), pp. 4045 - 4055
dc.identifier.issn 0270-6474
dc.description.abstract The beta-adrenergic receptor kinase (beta ARK) phosphorylates the agonist-occupied beta-adrenergic receptor to promote rapid receptor uncoupling from Gs, thereby attenuating adenylyl cyclase activity. Beta ARK-mediated receptor desensitization may reflect a general molecular mechanism operative on many G-protein-coupled receptor systems and, particularly, synaptic neurotransmitter receptors. Two distinct cDNAs encoding beta ARK isozymes were isolated from rat brain and sequenced. The regional and cellular distributions of these two gene products, termed beta ARK1 and beta ARK2, were determined in brain by in situ hybridization and by immunohistochemistry at the light and electron microscopic levels. The beta ARK isozymes were found to be expressed primarily in neurons distributed throughout the CNS. Ultrastructurally, beta ARK1 and beta ARK2 immunoreactivities were present both in association with postsynaptic densities and, presynaptically, with axon terminals. The beta ARK isozymes have a regional and subcellular distribution consistent with a general role in the desensitization of synaptic receptors.
dc.format.extent 4045 - 4055
dc.language eng
dc.relation.ispartof J Neurosci
dc.subject Amino Acid Sequence
dc.subject Animals
dc.subject Brain
dc.subject Brain Chemistry
dc.subject Cyclic AMP-Dependent Protein Kinases
dc.subject GTP-Binding Proteins
dc.subject Molecular Sequence Data
dc.subject Proteins
dc.subject Rats
dc.subject Synapses
dc.subject beta-Adrenergic Receptor Kinases
dc.title The G-protein-coupled receptor kinases beta ARK1 and beta ARK2 are widely distributed at synapses in rat brain.
dc.type Journal Article
duke.description.endpage 4055 en_US
duke.description.issue 10 en_US
duke.description.startpage 4045 en_US
duke.description.volume 12 en_US
dc.relation.journal Journal of Neuroscience en_US
pubs.issue 10
pubs.organisational-group /Duke
pubs.organisational-group /Duke/Institutes and Provost's Academic Units
pubs.organisational-group /Duke/Institutes and Provost's Academic Units/University Institutes and Centers
pubs.organisational-group /Duke/Institutes and Provost's Academic Units/University Institutes and Centers/Duke Institute for Brain Sciences
pubs.organisational-group /Duke/School of Medicine
pubs.organisational-group /Duke/School of Medicine/Basic Science Departments
pubs.organisational-group /Duke/School of Medicine/Basic Science Departments/Biochemistry
pubs.organisational-group /Duke/School of Medicine/Basic Science Departments/Cell Biology
pubs.organisational-group /Duke/School of Medicine/Basic Science Departments/Neurobiology
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Medicine
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Medicine/Medicine, Cardiology
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Pathology
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers/Duke Cancer Institute
pubs.organisational-group /Duke/Trinity College of Arts & Sciences
pubs.organisational-group /Duke/Trinity College of Arts & Sciences/Chemistry
pubs.publication-status Published
pubs.volume 12

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