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The G-protein-coupled receptor kinases beta ARK1 and beta ARK2 are widely distributed at synapses in rat brain.

dc.contributor.author Arriza, JL
dc.contributor.author Dawson, TM
dc.contributor.author Simerly, RB
dc.contributor.author Martin, LJ
dc.contributor.author Caron, MG
dc.contributor.author Snyder, SH
dc.contributor.author Lefkowitz, RJ
dc.coverage.spatial United States
dc.date.accessioned 2012-10-23T22:17:17Z
dc.date.issued 1992-10
dc.identifier https://www.ncbi.nlm.nih.gov/pubmed/1403099
dc.identifier.issn 0270-6474
dc.identifier.uri https://hdl.handle.net/10161/5918
dc.description.abstract The beta-adrenergic receptor kinase (beta ARK) phosphorylates the agonist-occupied beta-adrenergic receptor to promote rapid receptor uncoupling from Gs, thereby attenuating adenylyl cyclase activity. Beta ARK-mediated receptor desensitization may reflect a general molecular mechanism operative on many G-protein-coupled receptor systems and, particularly, synaptic neurotransmitter receptors. Two distinct cDNAs encoding beta ARK isozymes were isolated from rat brain and sequenced. The regional and cellular distributions of these two gene products, termed beta ARK1 and beta ARK2, were determined in brain by in situ hybridization and by immunohistochemistry at the light and electron microscopic levels. The beta ARK isozymes were found to be expressed primarily in neurons distributed throughout the CNS. Ultrastructurally, beta ARK1 and beta ARK2 immunoreactivities were present both in association with postsynaptic densities and, presynaptically, with axon terminals. The beta ARK isozymes have a regional and subcellular distribution consistent with a general role in the desensitization of synaptic receptors.
dc.language eng
dc.publisher Society for Neuroscience
dc.relation.ispartof J Neurosci
dc.subject Amino Acid Sequence
dc.subject Animals
dc.subject Brain
dc.subject Brain Chemistry
dc.subject Cyclic AMP-Dependent Protein Kinases
dc.subject GTP-Binding Proteins
dc.subject Molecular Sequence Data
dc.subject Proteins
dc.subject Rats
dc.subject Synapses
dc.subject beta-Adrenergic Receptor Kinases
dc.title The G-protein-coupled receptor kinases beta ARK1 and beta ARK2 are widely distributed at synapses in rat brain.
dc.type Journal article
duke.contributor.id Caron, MG|0112275
duke.contributor.id Lefkowitz, RJ|0096962
duke.description.issue 10
duke.description.volume 12
dc.relation.journal Journal of Neuroscience
pubs.author-url https://www.ncbi.nlm.nih.gov/pubmed/1403099
pubs.begin-page 4045
pubs.end-page 4055
pubs.issue 10
pubs.organisational-group Basic Science Departments
pubs.organisational-group Biochemistry
pubs.organisational-group Cell Biology
pubs.organisational-group Chemistry
pubs.organisational-group Clinical Science Departments
pubs.organisational-group Duke
pubs.organisational-group Duke Cancer Institute
pubs.organisational-group Duke Institute for Brain Sciences
pubs.organisational-group Institutes and Centers
pubs.organisational-group Institutes and Provost's Academic Units
pubs.organisational-group Medicine
pubs.organisational-group Medicine, Cardiology
pubs.organisational-group Neurobiology
pubs.organisational-group Pathology
pubs.organisational-group School of Medicine
pubs.organisational-group Trinity College of Arts & Sciences
pubs.organisational-group University Institutes and Centers
pubs.publication-status Published
pubs.volume 12


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