Mitogenic signaling via G protein-coupled receptors.
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Calcium-Calmodulin-Dependent Protein Kinases
Gene Expression Regulation, Enzymologic
Receptors, Cell Surface
Published Version (Please cite this version)10.1210/edrv-17-6-698
Publication InfoHawes, BE; Lefkowitz, Robert J; Luttrell, LM; & van Biesen, T (1996). Mitogenic signaling via G protein-coupled receptors. Endocr Rev, 17(6). pp. 698-714. 10.1210/edrv-17-6-698. Retrieved from http://hdl.handle.net/10161/5921.
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James B. Duke Professor of Medicine
The focus of work in this laboratory is on the elucidation of the molecular properties and regulatory mechanisms controlling the function of G protein-coupled receptors. As model systems we utilize the so called adrenergic receptors for adrenaline and related molecules. The goal is to learn the general principles of signal transduction from the outside to the inside of the cell which are involved in systems as diverse as sensory perception, neuro- transmitter and hormonal signaling. Stud