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Heptahelical receptor signaling: beyond the G protein paradigm.

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Date
1999-05-31
Authors
Hall, RA
Lefkowitz, Robert J
Premont, Richard Thomas
Repository Usage Stats
299
views
214
downloads
Type
Journal article
Subject
Animals
GTP-Binding Proteins
Humans
Receptor Protein-Tyrosine Kinases
Receptors, Cell Surface
Signal Transduction
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https://hdl.handle.net/10161/5922
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Scholars@Duke

Lefkowitz

Robert J. Lefkowitz

The Chancellor's Distinguished Professor of Medicine
Dr. Lefkowitz’s memoir, A Funny Thing Happened on the Way to Stockholm, recounts his early career as a cardiologist and his transition to biochemistry, which led to his Nobel Prize win. Robert J. Lefkowitz, M.D. is James B. Duke Professor of Medicine and Professor of Biochemistry and Chemistry at the Duke University Medical Center. He has been an Investigator of the
Premont

Richard Thomas Premont

Associate Professor in Medicine
Critical physiological events throughout the body are controlled by extracellular signals from neurotransmitters and hormones acting on cell surface receptors. Receptors transduce these signals to alter intracellular metabolism and cellular responsiveness through heterotrimeric G protein/second messenger pathways or through small GTP-binding protein/protein kinase cascades. The mechanisms that control the responsiveness of target organ G protein-coupled receptors include receptor ph
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