Anti-beta(1)-adrenergic receptor antibodies and heart failure: causation, not just correlation.
Repository Usage Stats
Antibodies specific for the beta(1)-adrenergic receptor are found in patients with chronic heart failure of various etiologies. From work presented in this issue of the JCI, we can now infer that these antibodies actually contribute to the pathogenesis of chronic heart failure. This commentary discusses mechanisms by which these antibodies may engender cardiomyopathy.
Receptors, Adrenergic, beta-1
Published Version (Please cite this version)10.1172/JCI21748
Publication InfoFreedman, Neil J; & Lefkowitz, Robert J (2004). Anti-beta(1)-adrenergic receptor antibodies and heart failure: causation, not just correlation. J Clin Invest, 113(10). pp. 1379-1382. 10.1172/JCI21748. Retrieved from https://hdl.handle.net/10161/5930.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
More InfoShow full item record
Professor of Medicine
Our work focuses on atherosclerosis-related signal transduction and the genetic bases of atherosclerosis and vein graft failure, both in vitro and in vivo. We investigate the regulation of receptor protein tyrosine kinases by G protein-coupled receptor kinases (GRKs), and the role of GRKs and β-arrestins in atherosclerosis; the role of tumor necrosis factor and its receptors in atherosclerosis; and the role of the dual Rho-GEF kalirin in atherosclerosis. For in vivo modeling of athe
James B. Duke Distinguished Professor of Medicine
Dr. Lefkowitz’s memoir, A Funny Thing Happened on the Way to Stockholm, recounts his early career as a cardiologist and his transition to biochemistry, which led to his Nobel Prize win. Robert J. Lefkowitz, M.D. is James B. Duke Professor of Medicine and Professor of Biochemistry and Chemistry at the Duke University Medical Center. He has been an Investigator of the
Alphabetical list of authors with Scholars@Duke profiles.