Anti-beta(1)-adrenergic receptor antibodies and heart failure: causation, not just correlation.
Abstract
Antibodies specific for the beta(1)-adrenergic receptor are found in patients with
chronic heart failure of various etiologies. From work presented in this issue of
the JCI, we can now infer that these antibodies actually contribute to the pathogenesis
of chronic heart failure. This commentary discusses mechanisms by which these antibodies
may engender cardiomyopathy.
Type
Journal articleSubject
Adrenergic beta-AntagonistsAutoantibodies
Heart Failure
Humans
Models, Cardiovascular
Myocardium
Receptors, Adrenergic, beta-1
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https://hdl.handle.net/10161/5930Published Version (Please cite this version)
10.1172/JCI21748Publication Info
(2004). Anti-beta(1)-adrenergic receptor antibodies and heart failure: causation, not just
correlation. J Clin Invest, 113(10). pp. 1379-1382. 10.1172/JCI21748. Retrieved from https://hdl.handle.net/10161/5930.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
Neil Jonathan Freedman
Professor of Medicine
Our work focuses on atherosclerosis-related signal transduction and the genetic bases
of atherosclerosis and vein graft failure, both in vitro and in vivo. We investigate
the regulation of receptor protein tyrosine kinases by G protein-coupled receptor
kinases (GRKs), and the role of GRKs and β-arrestins in atherosclerosis; the
role of tumor necrosis factor and its receptors in atherosclerosis; and the role of
the dual Rho-GEF kalirin in atherosclerosis. For in vivo modeling of athe
Robert J. Lefkowitz
James B. Duke Distinguished Professor of Medicine
Dr. Lefkowitz’s memoir, A Funny Thing Happened on the Way to Stockholm, recounts his
early career as a cardiologist and his transition to biochemistry, which led to his
Nobel Prize win.
Robert J. Lefkowitz, M.D. is James B. Duke Professor of Medicine and Professor of
Biochemistry and Chemistry at the Duke University Medical Center. He has been an Investigator
of the
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