Anti-beta(1)-adrenergic receptor antibodies and heart failure: causation, not just correlation.
Abstract
Antibodies specific for the beta(1)-adrenergic receptor are found in patients with
chronic heart failure of various etiologies. From work presented in this issue of
the JCI, we can now infer that these antibodies actually contribute to the pathogenesis
of chronic heart failure. This commentary discusses mechanisms by which these antibodies
may engender cardiomyopathy.
Type
Journal articleSubject
Adrenergic beta-AntagonistsAutoantibodies
Heart Failure
Humans
Models, Cardiovascular
Myocardium
Receptors, Adrenergic, beta-1
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https://hdl.handle.net/10161/5930Published Version (Please cite this version)
10.1172/JCI21748Publication Info
(2004). Anti-beta(1)-adrenergic receptor antibodies and heart failure: causation, not just
correlation. J Clin Invest, 113(10). pp. 1379-1382. 10.1172/JCI21748. Retrieved from https://hdl.handle.net/10161/5930.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
Neil Jonathan Freedman
Professor of Medicine
Our work focuses on atherosclerosis-related signal transduction and the genetic bases
of atherosclerosis and vein graft failure, both in vitro and in vivo. We investigate
the regulation of receptor protein tyrosine kinases by G protein-coupled receptor
kinases (GRKs), and the role of GRKs and β-arrestins in atherosclerosis; the
role of tumor necrosis factor and its receptors in atherosclerosis; and the role of
the dual Rho-GEF kalirin in atherosclerosis. For in vivo modeling of athe
Robert J. Lefkowitz
James B. Duke Distinguished Professor of Medicine
The focus of work in this laboratory is on the elucidation of the molecular properties
and regulatory mechanisms controlling the function of G protein-coupled receptors.
As model systems we utilize the so called adrenergic receptors for adrenaline and
related molecules. The goal is to learn the general principles of signal transduction
from the outside to the inside of the cell which are involved in systems as diverse
as sensory perception, neuro- transmitter and hormonal signaling. Stud
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