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    Anti-beta(1)-adrenergic receptor antibodies and heart failure: causation, not just correlation.

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    Date
    2004-05
    Authors
    Freedman, NJ
    Lefkowitz, Robert J
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    Abstract
    Antibodies specific for the beta(1)-adrenergic receptor are found in patients with chronic heart failure of various etiologies. From work presented in this issue of the JCI, we can now infer that these antibodies actually contribute to the pathogenesis of chronic heart failure. This commentary discusses mechanisms by which these antibodies may engender cardiomyopathy.
    Type
    Journal article
    Subject
    Adrenergic beta-Antagonists
    Autoantibodies
    Heart Failure
    Humans
    Models, Cardiovascular
    Myocardium
    Receptors, Adrenergic, beta-1
    Permalink
    https://hdl.handle.net/10161/5930
    Published Version (Please cite this version)
    10.1172/JCI21748
    Publication Info
    Freedman, NJ; & Lefkowitz, Robert J (2004). Anti-beta(1)-adrenergic receptor antibodies and heart failure: causation, not just correlation. J Clin Invest, 113(10). pp. 1379-1382. 10.1172/JCI21748. Retrieved from https://hdl.handle.net/10161/5930.
    This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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    Scholars@Duke

    Lefkowitz

    Robert J. Lefkowitz

    James B. Duke Distinguished Professor of Medicine
    The focus of work in this laboratory is on the elucidation of the molecular properties and regulatory mechanisms controlling the function of G protein-coupled receptors. As model systems we utilize the so called adrenergic receptors for adrenaline and related molecules. The goal is to learn the general principles of signal transduction from the outside to the inside of the cell which are involved in systems as diverse as sensory perception, neuro- transmitter and hormonal signaling. Stud
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    Articles written by Duke faculty are made available through the campus open access policy. For more information see: Duke Open Access Policy

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