Show simple item record

When 7 transmembrane receptors are not G protein-coupled receptors.

dc.contributor.author Rajagopal, Keshava
dc.contributor.author Lefkowitz, Robert J
dc.contributor.author Rockman, Howard A
dc.coverage.spatial United States
dc.date.accessioned 2012-10-24T18:35:24Z
dc.date.issued 2005-11
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/16276410
dc.identifier.issn 0021-9738
dc.identifier.uri https://hdl.handle.net/10161/5931
dc.description.abstract Classically, 7 transmembrane receptors transduce extracellular signals by coupling to heterotrimeric G proteins, although recent in vitro studies have clearly demonstrated that they can also signal via G protein-independent mechanisms. However, the physiologic consequences of this unconventional signaling, particularly in vivo, have not been explored. In this issue of the JCI, Zhai et al. demonstrate in vivo effects of G protein-independent signaling by the angiotensin II type 1 receptor (AT1R) (see the related article beginning on page 3045). In studies of the mouse heart, they compare the physiologic and biochemical consequences of transgenic cardiac-specific overexpression of a mutant AT1R incapable of G protein coupling with those of a wild-type receptor. Their results not only provide the first glimpse of the physiologic effects of this newly appreciated mode of signaling but also provide important and previously unappreciated clues as to the underlying molecular mechanisms.
dc.language eng
dc.publisher American Society for Clinical Investigation
dc.relation.ispartof J Clin Invest
dc.relation.isversionof 10.1172/JCI26950
dc.subject Animals
dc.subject Mice
dc.subject Receptor, Angiotensin, Type 1
dc.subject Receptors, G-Protein-Coupled
dc.subject Signal Transduction
dc.title When 7 transmembrane receptors are not G protein-coupled receptors.
dc.type Journal article
duke.contributor.id Lefkowitz, Robert J|0096962
duke.contributor.id Rockman, Howard A|0223027
duke.description.issue 11
duke.description.volume 115
dc.relation.journal Journal of Clinical Investigation
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/16276410
pubs.begin-page 2971
pubs.end-page 2974
pubs.issue 11
pubs.organisational-group Basic Science Departments
pubs.organisational-group Biochemistry
pubs.organisational-group Cell Biology
pubs.organisational-group Chemistry
pubs.organisational-group Clinical Science Departments
pubs.organisational-group Duke
pubs.organisational-group Duke Cancer Institute
pubs.organisational-group Institutes and Centers
pubs.organisational-group Medicine
pubs.organisational-group Medicine, Cardiology
pubs.organisational-group Molecular Genetics and Microbiology
pubs.organisational-group Pathology
pubs.organisational-group School of Medicine
pubs.organisational-group Trinity College of Arts & Sciences
pubs.publication-status Published
pubs.volume 115


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record