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Trafficking of G protein-coupled receptors.

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Date
2006-09-15
Authors
Drake, Matthew T
Shenoy, Sudha K
Lefkowitz, Robert J
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Abstract
G protein-coupled receptors (GPCRs) play an integral role in the signal transduction of an enormous array of biological phenomena, thereby serving to modulate at a molecular level almost all components of human biology. This role is nowhere more evident than in cardiovascular biology, where GPCRs regulate such core measures of cardiovascular function as heart rate, contractility, and vascular tone. GPCR/ligand interaction initiates signal transduction cascades, and requires the presence of the receptor at the plasma membrane. Plasma membrane localization is in turn a function of the delivery of a receptor to and removal from the cell surface, a concept defined most broadly as receptor trafficking. This review illuminates our current view of GPCR trafficking, particularly within the cardiovascular system, as well as highlights the recent and provocative finding that components of the GPCR trafficking machinery can facilitate GPCR signaling independent of G protein activation.
Type
Journal article
Subject
Cardiovascular System
Endocytosis
Humans
Protein Transport
Receptors, G-Protein-Coupled
Signal Transduction
Permalink
https://hdl.handle.net/10161/5934
Published Version (Please cite this version)
10.1161/01.RES.0000242563.47507.ce
Publication Info
Drake, Matthew T; Shenoy, Sudha K; & Lefkowitz, Robert J (2006). Trafficking of G protein-coupled receptors. Circ Res, 99(6). pp. 570-582. 10.1161/01.RES.0000242563.47507.ce. Retrieved from https://hdl.handle.net/10161/5934.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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Scholars@Duke

Lefkowitz

Robert J. Lefkowitz

James B. Duke Distinguished Professor of Medicine
Dr. Lefkowitz’s memoir, A Funny Thing Happened on the Way to Stockholm, recounts his early career as a cardiologist and his transition to biochemistry, which led to his Nobel Prize win. Robert J. Lefkowitz, M.D. is James B. Duke Professor of Medicine and Professor of Biochemistry and Chemistry at the Duke University Medical Center. He has been an Investigator of the
Shenoy

Sudha Kaup Shenoy

Associate Professor in Medicine
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