Trafficking of G protein-coupled receptors.
Abstract
G protein-coupled receptors (GPCRs) play an integral role in the signal transduction
of an enormous array of biological phenomena, thereby serving to modulate at a molecular
level almost all components of human biology. This role is nowhere more evident than
in cardiovascular biology, where GPCRs regulate such core measures of cardiovascular
function as heart rate, contractility, and vascular tone. GPCR/ligand interaction
initiates signal transduction cascades, and requires the presence of the receptor
at the plasma membrane. Plasma membrane localization is in turn a function of the
delivery of a receptor to and removal from the cell surface, a concept defined most
broadly as receptor trafficking. This review illuminates our current view of GPCR
trafficking, particularly within the cardiovascular system, as well as highlights
the recent and provocative finding that components of the GPCR trafficking machinery
can facilitate GPCR signaling independent of G protein activation.
Type
Journal articleSubject
Cardiovascular SystemEndocytosis
Humans
Protein Transport
Receptors, G-Protein-Coupled
Signal Transduction
Permalink
https://hdl.handle.net/10161/5934Published Version (Please cite this version)
10.1161/01.RES.0000242563.47507.cePublication Info
Drake, Matthew T; Shenoy, Sudha K; & Lefkowitz, Robert J (2006). Trafficking of G protein-coupled receptors. Circ Res, 99(6). pp. 570-582. 10.1161/01.RES.0000242563.47507.ce. Retrieved from https://hdl.handle.net/10161/5934.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
Collections
More Info
Show full item recordScholars@Duke
Robert J. Lefkowitz
James B. Duke Distinguished Professor of Medicine
Dr. Lefkowitz’s memoir, A Funny Thing Happened on the Way to Stockholm, recounts his
early career as a cardiologist and his transition to biochemistry, which led to his
Nobel Prize win.
Robert J. Lefkowitz, M.D. is James B. Duke Professor of Medicine and Professor of
Biochemistry and Chemistry at the Duke University Medical Center. He has been an Investigator
of the
Sudha Kaup Shenoy
Associate Professor in Medicine
Alphabetical list of authors with Scholars@Duke profiles.

Articles written by Duke faculty are made available through the campus open access policy. For more information see: Duke Open Access Policy
Rights for Collection: Scholarly Articles
Works are deposited here by their authors, and represent their research and opinions, not that of Duke University. Some materials and descriptions may include offensive content. More info