Show simple item record Drake, MT Shenoy, SK Lefkowitz, RJ
dc.coverage.spatial United States 2012-10-24T20:09:46Z 2006-09-15
dc.identifier 99/6/570
dc.identifier.citation Circ Res, 2006, 99 (6), pp. 570 - 582
dc.description.abstract G protein-coupled receptors (GPCRs) play an integral role in the signal transduction of an enormous array of biological phenomena, thereby serving to modulate at a molecular level almost all components of human biology. This role is nowhere more evident than in cardiovascular biology, where GPCRs regulate such core measures of cardiovascular function as heart rate, contractility, and vascular tone. GPCR/ligand interaction initiates signal transduction cascades, and requires the presence of the receptor at the plasma membrane. Plasma membrane localization is in turn a function of the delivery of a receptor to and removal from the cell surface, a concept defined most broadly as receptor trafficking. This review illuminates our current view of GPCR trafficking, particularly within the cardiovascular system, as well as highlights the recent and provocative finding that components of the GPCR trafficking machinery can facilitate GPCR signaling independent of G protein activation.
dc.format.extent 570 - 582
dc.language eng
dc.relation.ispartof Circ Res
dc.relation.isversionof 10.1161/01.RES.0000242563.47507.ce
dc.subject Cardiovascular System
dc.subject Endocytosis
dc.subject Humans
dc.subject Protein Transport
dc.subject Receptors, G-Protein-Coupled
dc.subject Signal Transduction
dc.title Trafficking of G protein-coupled receptors.
dc.type Journal Article
duke.description.endpage 582 en_US
duke.description.issue 6 en_US
duke.description.startpage 570 en_US
duke.description.volume 99 en_US
dc.relation.journal Airculation Research en_US
pubs.issue 6
pubs.organisational-group /Duke
pubs.organisational-group /Duke/School of Medicine
pubs.organisational-group /Duke/School of Medicine/Basic Science Departments
pubs.organisational-group /Duke/School of Medicine/Basic Science Departments/Biochemistry
pubs.organisational-group /Duke/School of Medicine/Basic Science Departments/Cell Biology
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Medicine
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Medicine/Medicine, Cardiology
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Pathology
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers/Duke Cancer Institute
pubs.organisational-group /Duke/Trinity College of Arts & Sciences
pubs.organisational-group /Duke/Trinity College of Arts & Sciences/Chemistry
pubs.publication-status Published
pubs.volume 99
dc.identifier.eissn 1524-4571

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