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β-Adrenergic Receptor Kinase-1 Levels in Catecholamine-Induced Myocardial Hypertrophy

dc.contributor.author Dolber, Paul Christian
dc.contributor.author Iaccarino, Guido
dc.contributor.author Koch, Walter J
dc.contributor.author Lefkowitz, Robert J
dc.date.accessioned 2012-10-24T20:32:15Z
dc.date.available 2012-10-24T20:32:15Z
dc.date.issued 1999-01
dc.identifier.citation Iaccarino, G., P. C. Dolber, et al. (1999). "β-Adrenergic Receptor Kinase-1 Levels in Catecholamine-Induced Myocardial Hypertrophy." Hypertension 33(1): 396-401.
dc.identifier.uri https://hdl.handle.net/10161/5937
dc.description.abstract Pressure overload ventricular hypertrophy is accompanied by dysfunctional β-adrenergic receptor signaling due to increased levels of the β-adrenergic receptor kinase-1, which phosphorylates and desensitizes β-adrenergic receptors. In this study, we examined whether increased β-adrenergic receptor kinase 1 expression is associated with myocardial hypertrophy induced by adrenergic stimulation. With use of implanted mini-osmotic pumps, we treated mice with isoproterenol, phenylephrine, or vehicle to distinguish between α1- and β-adrenergic stimulation. Both treatments resulted in cardiac hypertrophy, but only isoproterenol induced significant increases in β-adrenergic receptor kinase-1 protein levels and activity. Similarly, in isolated adult rat cardiac myocytes, 24 hours of isoproterenol stimulation resulted in a significant 2.8-fold increase in β-adrenergic receptor kinase-1 protein levels, whereas 24 hours of phenylephrine treatment did not alter β-adrenergic receptor kinase-1 expression. Our results indicate that increased β-adrenergic receptor kinase-1 is not invariably associated with myocardial hypertrophy but apparently is controlled by the state of β-adrenergic receptor activation.
dc.publisher American Heart Association
dc.relation.isversionof 10.1161/01.HYP.33.1.396
dc.subject myocardial hypertrophy
dc.subject β-adrenergic receptor
dc.subject G protein–coupled receptor kinases
dc.subject desensitization
dc.subject catecholamines
dc.title β-Adrenergic Receptor Kinase-1 Levels in Catecholamine-Induced Myocardial Hypertrophy
dc.type Journal article
duke.description.issue 1
duke.description.volume 33
dc.relation.journal Hypertension
pubs.begin-page 396
pubs.end-page 401


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