Hybrid transgenic mice reveal in vivo specificity of G protein-coupled receptor kinases in the heart.
Atrial Natriuretic Factor
Cyclic AMP-Dependent Protein Kinases
G-Protein-Coupled Receptor Kinase 3
G-Protein-Coupled Receptor Kinase 5
JNK Mitogen-Activated Protein Kinases
Mitogen-Activated Protein Kinases
Receptors, Adrenergic, alpha
beta-Adrenergic Receptor Kinases
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Oppermann, M; Diversé-Pierluissi, M; Drazner, MH; Dyer, SL; Freedman, NJ; Peppel, KC; Lefkowitz, RJ (Proc Natl Acad Sci U S A, 1996-07-23)Guanine nucleotide-binding regulatory protein (G protein)-coupled receptor kinases (GRKs) constitute a family of serine/threonine kinases that play a major role in the agonist-induced phosphorylation and desensitization ...
Daaka, Y; Pitcher, JA; Richardson, M; Stoffel, RH; Robishaw, JD; Lefkowitz, RJ (Proc Natl Acad Sci U S A, 1997-03-18)The G protein-coupled receptor (GPCR) kinases (GRKs) phosphorylate and desensitize agonist-occupied GPCRs. GRK2-mediated receptor phosphorylation is preceded by the agonist-dependent membrane association of this enzyme. ...
Direct evidence that Gi-coupled receptor stimulation of mitogen-activated protein kinase is mediated by G beta gamma activation of p21ras. Koch, WJ; Hawes, BE; Allen, LF; Lefkowitz, RJ (Proc Natl Acad Sci U S A, 1994-12-20)Stimulation of Gi-coupled receptors leads to the activation of mitogen-activated protein kinases (MAP kinases). In several cell types, this appears to be dependent on the activation of p21ras (Ras). Which G-protein subunit(s) ...