Show simple item record Shah, SH Bain, JR Muehlbauer, MJ Stevens, RD Crosslin, DR Haynes, C Dungan, J Newby, LK Hauser, ER Ginsburg, GS Newgard, CB Kraus, WE
dc.coverage.spatial United States 2012-10-30T19:36:55Z 2010-04
dc.identifier CIRCGENETICS.109.852814
dc.identifier.citation Circ Cardiovasc Genet, 2010, 3 (2), pp. 207 - 214
dc.description.abstract BACKGROUND: Molecular tools may provide insight into cardiovascular risk. We assessed whether metabolites discriminate coronary artery disease (CAD) and predict risk of cardiovascular events. METHODS AND RESULTS: We performed mass-spectrometry-based profiling of 69 metabolites in subjects from the CATHGEN biorepository. To evaluate discriminative capabilities of metabolites for CAD, 2 groups were profiled: 174 CAD cases and 174 sex/race-matched controls ("initial"), and 140 CAD cases and 140 controls ("replication"). To evaluate the capability of metabolites to predict cardiovascular events, cases were combined ("event" group); of these, 74 experienced death/myocardial infarction during follow-up. A third independent group was profiled ("event-replication" group; n=63 cases with cardiovascular events, 66 controls). Analysis included principal-components analysis, linear regression, and Cox proportional hazards. Two principal components analysis-derived factors were associated with CAD: 1 comprising branched-chain amino acid metabolites (factor 4, initial P=0.002, replication P=0.01), and 1 comprising urea cycle metabolites (factor 9, initial P=0.0004, replication P=0.01). In multivariable regression, these factors were independently associated with CAD in initial (factor 4, odds ratio [OR], 1.36; 95% CI, 1.06 to 1.74; P=0.02; factor 9, OR, 0.67; 95% CI, 0.52 to 0.87; P=0.003) and replication (factor 4, OR, 1.43; 95% CI, 1.07 to 1.91; P=0.02; factor 9, OR, 0.66; 95% CI, 0.48 to 0.91; P=0.01) groups. A factor composed of dicarboxylacylcarnitines predicted death/myocardial infarction (event group hazard ratio 2.17; 95% CI, 1.23 to 3.84; P=0.007) and was associated with cardiovascular events in the event-replication group (OR, 1.52; 95% CI, 1.08 to 2.14; P=0.01). CONCLUSIONS: Metabolite profiles are associated with CAD and subsequent cardiovascular events.
dc.format.extent 207 - 214
dc.language eng
dc.relation.ispartof Circ Cardiovasc Genet
dc.relation.isversionof 10.1161/CIRCGENETICS.109.852814
dc.subject Adult
dc.subject Aged
dc.subject Biomarkers
dc.subject Coronary Artery Disease
dc.subject Female
dc.subject Humans
dc.subject Linear Models
dc.subject Male
dc.subject Mass Spectrometry
dc.subject Metabolome
dc.subject Middle Aged
dc.subject Myocardial Infarction
dc.subject Odds Ratio
dc.subject Principal Component Analysis
dc.subject Proportional Hazards Models
dc.subject ROC Curve
dc.subject Risk Factors
dc.title Association of a peripheral blood metabolic profile with coronary artery disease and risk of subsequent cardiovascular events.
dc.type Journal Article
duke.description.endpage 214 en_US
duke.description.issue 2 en_US
duke.description.startpage 207 en_US
duke.description.volume 3 en_US
dc.relation.journal Circulation: Cardiovasular Genetics en_US
pubs.issue 2
pubs.organisational-group /Duke
pubs.organisational-group /Duke/Institutes and Provost's Academic Units
pubs.organisational-group /Duke/Institutes and Provost's Academic Units/University Institutes and Centers
pubs.organisational-group /Duke/Institutes and Provost's Academic Units/University Institutes and Centers/Global Health Institute
pubs.organisational-group /Duke/Pratt School of Engineering
pubs.organisational-group /Duke/Pratt School of Engineering/Biomedical Engineering
pubs.organisational-group /Duke/School of Medicine
pubs.organisational-group /Duke/School of Medicine/Basic Science Departments
pubs.organisational-group /Duke/School of Medicine/Basic Science Departments/Biochemistry
pubs.organisational-group /Duke/School of Medicine/Basic Science Departments/Biostatistics & Bioinformatics
pubs.organisational-group /Duke/School of Medicine/Basic Science Departments/Pharmacology & Cancer Biology
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Medicine
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Medicine/Medicine, Cardiology
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Medicine/Medicine, Endocrinology, Metabolism, and Nutrition
pubs.organisational-group /Duke/School of Medicine/Clinical Science Departments/Pathology
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers/Center for the Study of Aging and Human Development
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers/Duke Cancer Institute
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers/Duke Clinical Research Institute
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers/Duke Molecular Physiology Institute
pubs.organisational-group /Duke/School of Medicine/Institutes and Centers/Duke Molecular Physiology Institute/Sarah Stedman Nutrition & Metabolism Center
pubs.organisational-group /Duke/School of Nursing
pubs.organisational-group /Duke/School of Nursing/School of Nursing - Secondary Group
pubs.publication-status Published
pubs.volume 3
dc.identifier.eissn 1942-3268

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