Towards a field-compatible optical spectroscopic device for cervical cancer screening in resource-limited settings: effects of calibration and pressure.
Abstract
Quantitative optical spectroscopy has the potential to provide an effective low cost,
and portable solution for cervical pre-cancer screening in resource-limited communities.
However, clinical studies to validate the use of this technology in resource-limited
settings require low power consumption and good quality control that is minimally
influenced by the operator or variable environmental conditions in the field. The
goal of this study was to evaluate the effects of two sources of potential error:
calibration and pressure on the extraction of absorption and scattering properties
of normal cervical tissues in a resource-limited setting in Leogane, Haiti. Our results
show that self-calibrated measurements improved scattering measurements through real-time
correction of system drift, in addition to minimizing the time required for post-calibration.
Variations in pressure (tested without the potential confounding effects of calibration
error) caused local changes in vasculature and scatterer density that significantly
impacted the tissue absorption and scattering properties Future spectroscopic systems
intended for clinical use, particularly where operator training is not viable and
environmental conditions unpredictable, should incorporate a real-time self-calibration
channel and collect diffuse reflectance spectra at a consistent pressure to maximize
data integrity.
Type
Journal articleSubject
Acetic AcidAdult
Calibration
Early Detection of Cancer
Female
Haiti
Humans
Middle Aged
Monte Carlo Method
Optical Devices
Phantoms, Imaging
Pressure
Sensitivity and Specificity
Spectrum Analysis
Uterine Cervical Neoplasms
Vaginal Smears
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https://hdl.handle.net/10161/5972Collections
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Show full item recordScholars@Duke
David Keith Walmer
Adjunct Professor of Global Health
My areas of interest include both 1. women's health in Haiti & 2. reproductive endocrinology
GLOBAL HEALTH Preventing cervical cancer in Haiti Goal: Develop culturally acceptable
and cost effective strategies to prevent cervical cancer Description: 1) Evaluating
strategies that can be Developing a center of excellence for women's health in rural
HaitiDescriptionRE

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