Now showing items 1-10 of 55
Determining the size of the male-specific region in the genome of the scuttle fly, Megaselia scalaris, a potential model system for the earliest stages of sex chromosome evolution
Modern day whole-genome sequencing and the ability to make comparisons across many taxa have significantly advanced the study of sex chromosome evolution. The scuttle fly, Megaselia scalaris, is an appropriate model system ...
Modeling developmental plasticity in variable environments through gene duplication: a case for phytochromes and gibberellin3-oxidases’ role in temperature-dependent seed germination
Seed germination is a critical developmental transition in plants and is regulated by complex combinations of environmental cues that restrict its timing to occur over the widest possible range of conditions suitable for ...
Developing Methods for Access to High Quality Genome Sequences from Wild Ape Populations
Modern evolutionary study of wild ape populations requires the collection of genomic DNA from individuals living in their natural habitat. In order to be maximally useful, these samples must be robust enough for the amplification ...
The Braveness of Jane
Combination Therapies of the Neurotransmitter-Targeting Drugs Dextromethorphan, Pyrilamine and Lorcaserin in a Rat Model of Nicotine Addiction
Given the current epidemic of nicotine dependence, the study of interactions between neurotransmitter receptor-targeting molecules to discover possible new forms of smoking cessation treatment is of great importance. Previous ...
Effects of mitochondrial dynamics genes, fzo-1 and drp-1, on dopaminergic neurodegeneration induced by environmental exposure in Caenorhabditis elegans, as a model of Parkinson’s disease
Parkinson’s disease (PD) is caused by degeneration of the dopaminergic neurons; environmental toxicants are hypothesized to play a role in PD etiology. Environmental toxicants can cause mitochondrial dysfunction through ...
Short-chain fatty acids are produced by zebrafish microbiota and influence glucose homeostasis
Increasingly, attention has been drawn to the association between gut microbiomes and host health, particularly to the production of short-chain fatty acids (SCFA) from indigestible carbohydrates by colonic microbiota. It ...
Intra-specific variation exists in the asexual reproductive success of the peat moss genus Sphagnum
Both sexual and asexual reproduction occur in plants, with each mode having certain benefits and detriments to the fitness of the organism. Occasionally, asexual reproduction seems to be so dominant within a species that ...
Designing a genetic toggle switch for E. coli that uses sequestration of a eukaryotic repressor as a mechanism for ultrasensitivity
Bistable gene expression—when a gene’s output can achieve and alternate between two distinct, stable states—plays a critical role in the regulation of various cell and developmental processes including cell-cycle progression, ...
Investigating the role of a polymorphism in the sequence of MYB7 and the evolution of flower color in the Clarkia clade Rhodanthos
Determining how genetic changes alter developmental processes to generate diversity of phenotypes is a major objective of evolutionary developmental biology. Color patterning in animals and plants are employed as model systems ...