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Quantitative Magnetic Susceptibility of the Developing Mouse Brain

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Date
2012
Author
Argyridis, Ioannis
Advisor
Liu, Chunlei
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Abstract

Cerebral development involves a complex cascade of events which are difficult

to visualize in vivo. In this study we combine information from Diffusion Tensor

Imaging (DTI) and Quantitative Susceptibility Mapping (QSM) on developing mouse

brains at five stages, for three central white matter (WM) regions. QSM can be calculated

using frequency shift Gradient Echo MR images acquired at high field. Extracted mean

values from small white matter regions of QSM brain maps depend on the orientation of

the neuronal fibers of each voxel to the main magnetic field B0. Using fiber tracking

information from DTI a correlation of the myelin content of regions of interest (ROI) to

the orientation of those fibers to B0 can be made. Plots of the myelin anisotropy, as it

increases with age, were generated with this method, suggesting that the neuronal axon

is paramagnetic while the myelin surrounding the axon is diamagnetic. In addition the

fractional anisotropy (FA) and the mean Apparent Diffusion Coefficient (ADC) of the

same ROI were plotted against age. Histological exams were also performed to evaluate

myelin and iron content. It is confirmed that the main source of magnetic susceptibility in WM

is the myelin content. The interpretation of all this brain data will provide valuable

information on the architecture of the brain during development and a more accurate

diagnosis in the case of a myelin degenerative disease.

Type
Master's thesis
Department
Medical Physics
Subject
Medical imaging and radiology
MRI
myelin
phase
susceptibility
Permalink
https://hdl.handle.net/10161/6196
Citation
Argyridis, Ioannis (2012). Quantitative Magnetic Susceptibility of the Developing Mouse Brain. Master's thesis, Duke University. Retrieved from https://hdl.handle.net/10161/6196.
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This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 United States License.

Rights for Collection: Masters Theses


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