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An integrated alcohol abuse and medical treatment model for patients with hepatitis C.

dc.contributor.author Bixby, P
dc.contributor.author Coward, L
dc.contributor.author Mannelli, Paolo
dc.contributor.author Muir, Andrew
dc.contributor.author Naggie, Susanna
dc.contributor.author Patkar, AA
dc.contributor.author Proeschold-Bell, RJ
dc.contributor.author Yao, Jia
dc.coverage.spatial United States
dc.date.accessioned 2013-01-28T16:12:36Z
dc.date.issued 2012-04
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/22134784
dc.identifier.uri https://hdl.handle.net/10161/6209
dc.description.abstract BACKGROUND: Patients with chronic hepatitis C virus (HCV) infection have high rates of alcohol consumption, which is associated with progression of fibrosis and lower response rates to HCV treatment. AIMS: This prospective cohort study examined the feasibility of a 24-week integrated alcohol and medical treatment to HCV-infected patients. METHODS: Patients were recruited from a hepatology clinic if they had an Alcohol Use Disorders Identification Test score >4 for women and >8 for men, suggesting hazardous alcohol consumption. The integrated model included patients receiving medical care and alcohol treatment within the same clinic. Alcohol treatment consisted of 6 months of group and individual therapy from an addictions specialist and consultation from a study team psychiatrist as needed. RESULTS: Sixty patients were initially enrolled, and 53 patients participated in treatment. The primary endpoint was the Addiction Severity Index (ASI) alcohol composite scores, which significantly decreased by 0.105 (41.7% reduction) between 0 and 3 months (P < 0.01) and by 0.128 (50.6% reduction) between 0 and 6 months (P < 0.01) after adjusting for covariates. Alcohol abstinence was reported by 40% of patients at 3 months and 44% at 6 months. Patients who did not become alcohol abstinent had reductions in their ASI alcohol composite scores from 0.298 at baseline to 0.219 (26.8% reduction) at 6 months (P = 0.08). CONCLUSION: This study demonstrated that an integrated model of alcohol treatment and medical care could be successfully implemented in a hepatology clinic with significant favorable impact on alcohol use and abstinence among patients with chronic HCV.
dc.language eng
dc.relation.ispartof Dig Dis Sci
dc.relation.isversionof 10.1007/s10620-011-1976-4
dc.subject Adult
dc.subject Aged
dc.subject Alcoholism
dc.subject Counseling
dc.subject Female
dc.subject Hepatitis C, Chronic
dc.subject Humans
dc.subject Male
dc.subject Middle Aged
dc.subject Patient Care Team
dc.subject Psychotherapy, Group
dc.subject Temperance
dc.title An integrated alcohol abuse and medical treatment model for patients with hepatitis C.
dc.type Journal article
duke.description.issue 4
duke.description.volume 57
dc.relation.journal Digestive Diseases and Sciences
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/22134784
pubs.begin-page 1083
pubs.end-page 1091
pubs.issue 4
pubs.organisational-group Clinical Science Departments
pubs.organisational-group Community and Family Medicine
pubs.organisational-group Community and Family Medicine, Community Health
pubs.organisational-group Duke
pubs.organisational-group Duke Clinical Research Institute
pubs.organisational-group Global Health Institute
pubs.organisational-group Institutes and Centers
pubs.organisational-group Institutes and Provost's Academic Units
pubs.organisational-group Medicine
pubs.organisational-group Medicine, Gastroenterology
pubs.organisational-group Medicine, Infectious Diseases
pubs.organisational-group Psychiatry & Behavioral Sciences
pubs.organisational-group Psychiatry & Behavioral Sciences, Addictions
pubs.organisational-group School of Medicine
pubs.organisational-group University Institutes and Centers
pubs.publication-status Published
pubs.volume 57
dc.identifier.eissn 1573-2568


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