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Chikungunya and dengue fever among hospitalized febrile patients in northern Tanzania.

dc.contributor.author Hertz, Julian T
dc.contributor.author Munishi, O Michael
dc.contributor.author Ooi, Eng Eong
dc.contributor.author Howe, Shiqin
dc.contributor.author Lim, Wen Yan
dc.contributor.author Chow, Angelia
dc.contributor.author Morrissey, Anne B
dc.contributor.author Bartlett, John A
dc.contributor.author Onyango, Jecinta J
dc.contributor.author Maro, Venance P
dc.contributor.author Kinabo, Grace D
dc.contributor.author Saganda, Wilbrod
dc.contributor.author Gubler, Duane J
dc.contributor.author Crump, John A
dc.coverage.spatial United States
dc.date.accessioned 2013-03-05T19:12:18Z
dc.date.issued 2012-01
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/22232469
dc.identifier 86/1/171
dc.identifier.uri https://hdl.handle.net/10161/6330
dc.description.abstract Consecutive febrile admissions were enrolled at two hospitals in Moshi, Tanzania. Confirmed acute Chikungunya virus (CHIKV), Dengue virus (DENV), and flavivirus infection were defined as a positive polymerase chain reaction (PCR) result. Presumptive acute DENV infection was defined as a positive anti-DENV immunoglobulin M (IgM) enzyme-linked immunsorbent assay (ELISA) result, and prior flavivirus exposure was defined as a positive anti-DENV IgG ELISA result. Among 870 participants, PCR testing was performed on 700 (80.5%). Of these, 55 (7.9%) had confirmed acute CHIKV infection, whereas no participants had confirmed acute DENV or flavivirus infection. Anti-DENV IgM serologic testing was performed for 747 (85.9%) participants, and of these 71 (9.5%) had presumptive acute DENV infection. Anti-DENV IgG serologic testing was performed for 751 (86.3%) participants, and of these 80 (10.7%) had prior flavivirus exposure. CHIKV infection was more common among infants and children than adults and adolescents (odds ratio [OR] 1.9, P = 0.026) and among HIV-infected patients with severe immunosuppression (OR 10.5, P = 0.007). CHIKV infection is an important but unrecognized cause of febrile illness in northern Tanzania. DENV or other closely related flaviviruses are likely also circulating.
dc.language eng
dc.publisher American Society of Tropical Medicine and Hygiene
dc.relation.ispartof Am J Trop Med Hyg
dc.relation.isversionof 10.4269/ajtmh.2012.11-0393
dc.subject Adolescent
dc.subject Adult
dc.subject Aged
dc.subject Aged, 80 and over
dc.subject Alphavirus Infections
dc.subject Antibodies, Viral
dc.subject Chikungunya Fever
dc.subject Chikungunya virus
dc.subject Child
dc.subject Child, Preschool
dc.subject Dengue
dc.subject Dengue Virus
dc.subject Female
dc.subject Fever
dc.subject Hospitalization
dc.subject Humans
dc.subject Immunoglobulin M
dc.subject Infant
dc.subject Male
dc.subject Middle Aged
dc.subject Prevalence
dc.subject Tanzania
dc.subject Young Adult
dc.title Chikungunya and dengue fever among hospitalized febrile patients in northern Tanzania.
dc.type Journal article
duke.contributor.id Hertz, Julian T|0479553
duke.contributor.id Bartlett, John A|0058484
duke.contributor.id Crump, John A|0231646
duke.description.issue 1
duke.description.volume 86
dc.relation.journal The American Journal of Tropical Medicine and Hygiene
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/22232469
pubs.begin-page 171
pubs.end-page 177
pubs.issue 1
pubs.organisational-group Clinical Science Departments
pubs.organisational-group Duke
pubs.organisational-group Duke Cancer Institute
pubs.organisational-group Duke Science & Society
pubs.organisational-group Global Health Institute
pubs.organisational-group Initiatives
pubs.organisational-group Institutes and Centers
pubs.organisational-group Institutes and Provost's Academic Units
pubs.organisational-group Medicine
pubs.organisational-group Medicine, Infectious Diseases
pubs.organisational-group School of Medicine
pubs.organisational-group School of Nursing
pubs.organisational-group School of Nursing - Secondary Group
pubs.organisational-group Surgery
pubs.organisational-group Surgery, Emergency Medicine
pubs.organisational-group University Institutes and Centers
pubs.publication-status Published
pubs.volume 86
dc.identifier.eissn 1476-1645
duke.contributor.orcid Hertz, Julian T|0000-0002-7396-4789


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