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    Leptospirosis among hospitalized febrile patients in northern Tanzania.

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    Date
    2011-08
    Authors
    Bartlett, John A
    Biggs, HM
    Bui, DM
    Crump, John Andrew
    Galloway, RL
    Kinabo, GD
    Maro, Venance P
    Morrissey, AB
    Onyango, JJ
    Saganda, W
    Shadomy, SV
    Stoddard, RA
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    Abstract
    We enrolled consecutive febrile admissions to two hospitals in Moshi, Tanzania. Confirmed leptospirosis was defined as a ≥ 4-fold increase in microscopic agglutination test (MAT) titer; probable leptospirosis as reciprocal MAT titer ≥ 800; and exposure to pathogenic leptospires as titer ≥ 100. Among 870 patients enrolled in the study, 453 (52.1%) had paired sera available, and 40 (8.8%) of these met the definition for confirmed leptospirosis. Of 832 patients with ≥ 1 serum sample available, 30 (3.6%) had probable leptospirosis and an additional 277 (33.3%) had evidence of exposure to pathogenic leptospires. Among those with leptospirosis the most common clinical diagnoses were malaria in 31 (44.3%) and pneumonia in 18 (25.7%). Leptospirosis was associated with living in a rural area (odds ratio [OR] 3.4, P < 0.001). Among those with confirmed leptospirosis, the predominant reactive serogroups were Mini and Australis. Leptospirosis is a major yet underdiagnosed cause of febrile illness in northern Tanzania, where it appears to be endemic.
    Type
    Journal article
    Subject
    Adolescent
    Adult
    Aged
    Aged, 80 and over
    Child
    Child, Preschool
    Endemic Diseases
    Female
    Fever
    Humans
    Infant
    Inpatients
    Leptospirosis
    Male
    Middle Aged
    Tanzania
    Young Adult
    Permalink
    https://hdl.handle.net/10161/6334
    Published Version (Please cite this version)
    10.4269/ajtmh.2011.11-0176
    Publication Info
    Bartlett, John A; Biggs, HM; Bui, DM; Crump, John Andrew; Galloway, RL; Kinabo, GD; ... Stoddard, RA (2011). Leptospirosis among hospitalized febrile patients in northern Tanzania. Am J Trop Med Hyg, 85(2). pp. 275-281. 10.4269/ajtmh.2011.11-0176. Retrieved from https://hdl.handle.net/10161/6334.
    This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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    Scholars@Duke

    John Andrew Crump

    Adjunct Professor in the Department of Medicine
    I am based in northern Tanzania where I am Site Leader for Duke University&#8217;s collaborative research program based at Kilimanjaro Christian Medical Centre and Director of Tanzania Operations for the Duke Global Health Institute. I oversee the design and implementation of research studies on infectious diseases, particularly febrile illness, invasive bacterial disease, HIV-associated opportunistic infections, clinical trials of antiretroviral therapy and prevention of mother-to-child tr
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    Articles written by Duke faculty are made available through the campus open access policy. For more information see: Duke Open Access Policy

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