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Leptospirosis among hospitalized febrile patients in northern Tanzania.

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Date
2011-08
Authors
Biggs, Holly M
Bui, Duy M
Galloway, Renee L
Stoddard, Robyn A
Shadomy, Sean V
Morrissey, Anne B
Bartlett, John A
Onyango, Jecinta J
Maro, Venance P
Kinabo, Grace D
Saganda, Wilbrod
Crump, John A
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(12 total)
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Abstract
We enrolled consecutive febrile admissions to two hospitals in Moshi, Tanzania. Confirmed leptospirosis was defined as a ≥ 4-fold increase in microscopic agglutination test (MAT) titer; probable leptospirosis as reciprocal MAT titer ≥ 800; and exposure to pathogenic leptospires as titer ≥ 100. Among 870 patients enrolled in the study, 453 (52.1%) had paired sera available, and 40 (8.8%) of these met the definition for confirmed leptospirosis. Of 832 patients with ≥ 1 serum sample available, 30 (3.6%) had probable leptospirosis and an additional 277 (33.3%) had evidence of exposure to pathogenic leptospires. Among those with leptospirosis the most common clinical diagnoses were malaria in 31 (44.3%) and pneumonia in 18 (25.7%). Leptospirosis was associated with living in a rural area (odds ratio [OR] 3.4, P < 0.001). Among those with confirmed leptospirosis, the predominant reactive serogroups were Mini and Australis. Leptospirosis is a major yet underdiagnosed cause of febrile illness in northern Tanzania, where it appears to be endemic.
Type
Journal article
Subject
Adolescent
Adult
Aged
Aged, 80 and over
Child
Child, Preschool
Endemic Diseases
Female
Fever
Humans
Infant
Inpatients
Leptospirosis
Male
Middle Aged
Tanzania
Young Adult
Permalink
https://hdl.handle.net/10161/6334
Published Version (Please cite this version)
10.4269/ajtmh.2011.11-0176
Publication Info
Biggs, Holly M; Bui, Duy M; Galloway, Renee L; Stoddard, Robyn A; Shadomy, Sean V; Morrissey, Anne B; ... Crump, John A (2011). Leptospirosis among hospitalized febrile patients in northern Tanzania. Am J Trop Med Hyg, 85(2). pp. 275-281. 10.4269/ajtmh.2011.11-0176. Retrieved from https://hdl.handle.net/10161/6334.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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Scholars@Duke

Bartlett

John Alexander Bartlett

Professor of Medicine
My clinical investigation is focused on the pathogenesis and treatment of HIV infection and its complications, especially in resource-limited settings. Key Words: HIV infection, AIDS, treatment strategies, treatment failure, co-infections, resource-limited settings
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