Reduction of malaria prevalence by indoor residual spraying: a meta-regression analysis.
Abstract
Indoor residual spraying (IRS) has become an increasingly popular method of insecticide
use for malaria control, and many recent studies have reported on its effectiveness
in reducing malaria burden in a single community or region. There is a need for systematic
review and integration of the published literature on IRS and the contextual determining
factors of its success in controlling malaria. This study reports the findings of
a meta-regression analysis based on 13 published studies, which were chosen from more
than 400 articles through a systematic search and selection process. The summary relative
risk for reducing malaria prevalence was 0.38 (95% confidence interval = 0.31-0.46),
which indicated a risk reduction of 62%. However, an excessive degree of heterogeneity
was found between the studies. The meta-regression analysis indicates that IRS is
more effective with high initial prevalence, multiple rounds of spraying, use of DDT,
and in regions with a combination of Plasmodium falciparum and P. vivax malaria.
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Journal articlePermalink
https://hdl.handle.net/10161/6472Published Version (Please cite this version)
10.4269/ajtmh.2012.11-0620Publication Info
Kim, Dohyeong; Fedak, Kristen; & Kramer, Randall (2012). Reduction of malaria prevalence by indoor residual spraying: a meta-regression analysis.
Am J Trop Med Hyg, 87(1). pp. 117-124. 10.4269/ajtmh.2012.11-0620. Retrieved from https://hdl.handle.net/10161/6472.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Randall Kramer
Juli Plant Grainger Professor Emeritus of Global Environmental Health
Before coming to Duke in 1988, he was on the faculty at Virginia Polytechnic Institute
and State University. He has held visiting positions at IUCN--The World Conservation
Union, the Economic Growth Center at Yale University, and the Indonesian Ministry
of Forestry. He has served as a consultant to the World Bank, World Health Organization
and other international organizations. He was named Duke University's Scholar Teacher
of the Year in 2004.
Kramer's research is focused on the econ

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