Spectrum of a linearized amplitude equation for alternans in a cardiac fiber
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Under rapid periodic pacing, cardiac cells typically undergo a period-doubling bifurcation in which action potentials of short and long duration alternate with one another. If these action potentials propagate in a fiber, the short-long alternation may suffer reversals of phase at various points along the fiber, a phenomenon called (spatially) discordant alternans. Either stationary or moving patterns are possible. Using a weak approximation, Echebarria and Karma proposed an equation to describe the spatiotemporal dynamics of small-amplitude alternans in a class of simple cardiac models, and they showed that an instability in this equation predicts the spontaneous formation of discordant alternans. To study the bifurcation, they computed the spectrum of the relevant linearized operator numerically, supplemented with partial analytical results. In the present paper we calculate this spectrum with purely analytical methods in two cases where a small parameter may be exploited: (i) small dispersion or (ii) a long fiber. From this analysis we estimate the parameter ranges in which the phase reversals of discordant alternans are stationary or moving. © 2008 Society for Industrial and Applied Mathematics.
Published Version (Please cite this version)10.1137/070711384
Publication InfoDai, Shu; & Schaeffer, David G (2008). Spectrum of a linearized amplitude equation for alternans in a cardiac fiber. SIAM Journal on Applied Mathematics, 69(3). pp. 704-719. 10.1137/070711384. Retrieved from https://hdl.handle.net/10161/6957.
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James B. Duke Distinguished Professor Emeritus of Mathematics
Granular flow Although I worked in granular flow for 15 years, I largely stopped working in this area around 5 years ago. Part of my fascination with this field derived from the fact that typically constitutive equations derived from engineering approximations lead to ill-posed PDE. However, I came to believe that the lack of well-posed governing equations was the major obstacle to progress in the field, and I believe that finding appropriate constitutive relations is a task b