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dc.contributor.authorPelphrey, KA
dc.contributor.authorMack, PB
dc.contributor.authorSong, A
dc.contributor.authorGüzeldere, G
dc.contributor.authorMcCarthy, G
dc.coverage.spatialEngland
dc.date.accessioned2013-04-29T19:27:53Z
dc.date.issued2003-05-23
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/12802182
dc.identifier.issn0959-4965
dc.identifier.urihttp://hdl.handle.net/10161/6962
dc.description.abstractUsing fMRI techniques sensitive to blood oxygen-level dependent (BOLD) contrast, we measured brain activity in participants (n=8) as they viewed images of faces presented periodically within a continuously changing montage of common objects. Consistent with prior studies, we identified regions of ventral extrastriate cortex, primarily in the fusiform and inferior temporal gyri and nearby cortex, that were activated by faces as measured by an increase in BOLD signal. In addition, we made the novel observation that faces deactivated other areas of ventral extrastriate cortex, primarily in the lingual and parahippocampal gyri and medial to activations. These deactivated regions, identified by a decrease in BOLD signal, may reflect populations of neurons that decrease their activity when faces appear, possibly as a consequence of category-specific inhibition.
dc.languageeng
dc.relation.ispartofNeuroreport
dc.relation.isversionof10.1097/01.wnr.0000074345.81633.ad
dc.subjectAdult
dc.subjectBrain
dc.subjectBrain Mapping
dc.subjectFace
dc.subjectFemale
dc.subjectHumans
dc.subjectMagnetic Resonance Imaging
dc.subjectMale
dc.subjectPhotic Stimulation
dc.titleFaces evoke spatially differentiated patterns of BOLD activation and deactivation.
dc.typeJournal article
pubs.author-urlhttp://www.ncbi.nlm.nih.gov/pubmed/12802182
pubs.begin-page955
pubs.end-page959
pubs.issue7
pubs.organisational-groupBasic Science Departments
pubs.organisational-groupBiomedical Engineering
pubs.organisational-groupClinical Science Departments
pubs.organisational-groupDuke
pubs.organisational-groupDuke Cancer Institute
pubs.organisational-groupDuke Institute for Brain Sciences
pubs.organisational-groupInstitutes and Centers
pubs.organisational-groupInstitutes and Provost's Academic Units
pubs.organisational-groupNeurobiology
pubs.organisational-groupPratt School of Engineering
pubs.organisational-groupPsychiatry & Behavioral Sciences
pubs.organisational-groupRadiology
pubs.organisational-groupSchool of Medicine
pubs.organisational-groupUniversity Institutes and Centers
pubs.publication-statusPublished
pubs.volume14


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