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Chemical and biological applications of digital-microfluidic devices

dc.contributor.author Fair, RB
dc.contributor.author Khlystov, A
dc.contributor.author Tailor, TD
dc.contributor.author Ivanov, V
dc.contributor.author Evans, RD
dc.contributor.author Srinivasan, V
dc.contributor.author Pamula, VK
dc.contributor.author Pollack, MG
dc.contributor.author Griffin, PB
dc.contributor.author Zhou, J
dc.date.accessioned 2013-05-01T18:17:39Z
dc.date.issued 2007-01-01
dc.identifier.issn 0740-7475
dc.identifier.uri https://hdl.handle.net/10161/6987
dc.description.abstract The advent of digital microfluidic lab-on-a-chip (LoC) technology offers a platform for developing diagnostic applications with the advantages of portability, reduction of the volumes of the sample and reagents, faster analysis times, increased automation, low power consumption, compatibility with mass manufacturing, and high throughput. Moreover, digital microfluidics is being applied in other areas such as airborne chemical detection, DNA sequencing by synthesis, and tissue engineering. In most diagnostic and chemical-detection applications, a key challenge is the preparation of the analyte for presentation to the on-chip detection system. Thus, in diagnostics, raw physiological samples must be introduced onto the chip and then further processed by lysing blood cells and extracting DNA. For massively parallel DNA sequencing, sample preparation can be performed off chip, but the synthesis steps must be performed in a sequential on-chip format by automated control of buffers and nucleotides to extend the read lengths of DNA fragments. In airborne particulate-sampling applications, the sample collection from an air stream must be integrated into the LoC analytical component, which requires a collection droplet to scan an exposed impacted surface after its introduction into a closed analytical section. Finally, in tissue-engineering applications, the challenge for LoC technology is to build high-resolution (less than 10 microns) 3D tissue constructs with embedded cells and growth factors by manipulating and maintaining live cells in the chip platform. This article discusses these applications and their implementation in digital-microfluidic LoC platforms. © 2007 IEEE.
dc.publisher Institute of Electrical and Electronics Engineers (IEEE)
dc.relation.ispartof IEEE Design and Test of Computers
dc.relation.isversionof 10.1109/MDT.2007.8
dc.title Chemical and biological applications of digital-microfluidic devices
dc.type Journal article
duke.contributor.id Fair, RB|0099976
duke.contributor.id Khlystov, A|0312531
duke.contributor.id Tailor, TD|0293310
pubs.begin-page 10
pubs.end-page 24
pubs.issue 1
pubs.organisational-group Clinical Science Departments
pubs.organisational-group Duke
pubs.organisational-group Duke Science & Society
pubs.organisational-group Electrical and Computer Engineering
pubs.organisational-group Faculty
pubs.organisational-group Initiatives
pubs.organisational-group Institutes and Provost's Academic Units
pubs.organisational-group Pratt School of Engineering
pubs.organisational-group Radiology
pubs.organisational-group Radiology, Cardiothoracic Imaging
pubs.organisational-group School of Medicine
pubs.publication-status Published
pubs.volume 24


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