beta-arrestin-1 competitively inhibits insulin-induced ubiquitination and degradation of insulin receptor substrate 1
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Published Version (Please cite this version)10.1128/MCB.24.20.8929-8937.2004
Publication InfoHuang, J; Hupfeld, CJ; Imamura, T; Lefkowitz, Robert J; Olefsky, JM; Satoh, H; ... Usui, I (2004). beta-arrestin-1 competitively inhibits insulin-induced ubiquitination and degradation of insulin receptor substrate 1. MOLECULAR AND CELLULAR BIOLOGY, 24(20). pp. 8929-8937. 10.1128/MCB.24.20.8929-8937.2004. Retrieved from http://hdl.handle.net/10161/7793.
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James B. Duke Professor of Medicine
The focus of work in this laboratory is on the elucidation of the molecular properties and regulatory mechanisms controlling the function of G protein-coupled receptors. As model systems we utilize the so called adrenergic receptors for adrenaline and related molecules. The goal is to learn the general principles of signal transduction from the outside to the inside of the cell which are involved in systems as diverse as sensory perception, neuro- transmitter and hormonal signaling. Stud