Anti–β1-adrenergic receptor antibodies and heart failure: causation, not just correlation
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Published Version (Please cite this version)10.1172/JCI200421748
Publication InfoFreedman, NJ; & Lefkowitz, Robert J (2004). Anti–β1-adrenergic receptor antibodies and heart failure: causation, not just correlation. Journal of Clinical Investigation, 113(10). pp. 1379-1382. 10.1172/JCI200421748. Retrieved from https://hdl.handle.net/10161/7795.
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James B. Duke Distinguished Professor of Medicine
The focus of work in this laboratory is on the elucidation of the molecular properties and regulatory mechanisms controlling the function of G protein-coupled receptors. As model systems we utilize the so called adrenergic receptors for adrenaline and related molecules. The goal is to learn the general principles of signal transduction from the outside to the inside of the cell which are involved in systems as diverse as sensory perception, neuro- transmitter and hormonal signaling. Stud