Phosphorylation of cell surface receptors: a mechanism for regulating signal transduction pathways.
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Receptor, Epidermal Growth Factor
Receptors, Adrenergic, beta
Receptors, Cell Surface
Published Version (Please cite this version)10.1210/edrv-9-1-38
Publication InfoSibley, DR; Benovic, JL; Caron, MG; & Lefkowitz, RJ (1988). Phosphorylation of cell surface receptors: a mechanism for regulating signal transduction pathways. Endocr Rev, 9(1). pp. 38-56. 10.1210/edrv-9-1-38. Retrieved from https://hdl.handle.net/10161/7872.
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James B. Duke Distinguished Professor of Cell Biology
Studies of the mechanisms of action and regulation of hormones and neurotransmitters at the cellular and molecular levels constitute the main goals our of research activities. G protein-coupled receptors (GPCR) mediate the actions of signaling molecules from unicellular organisms to man. We have used adrenergic and dopamine receptors to characterize the structure/function and regulation mechanisms of these prototypes of G protein-coupled receptors. Another approach has been to characterize
James B. Duke Distinguished Professor of Medicine
Dr. Lefkowitz’s memoir, A Funny Thing Happened on the Way to Stockholm, recounts his early career as a cardiologist and his transition to biochemistry, which led to his Nobel Prize win. Robert J. Lefkowitz, M.D. is James B. Duke Professor of Medicine and Professor of Biochemistry and Chemistry at the Duke University Medical Center. He has been an Investigator of the
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Claing, A; Perry, SJ; Achiriloaie, M; Walker, JK; Albanesi, JP; Lefkowitz, RJ; Premont, RT (Proc Natl Acad Sci U S A, 2000-02-01)Recently, we identified a GTPase-activating protein for the ADP ribosylation factor family of small GTP-binding proteins that we call GIT1. This protein initially was identified as an interacting partner for the G protein-coupled ...
Lee, Claudia; Viswanathan, Gayathri; Choi, Issac; Jassal, Chanpreet; Kohlmann, Taylor; Rajagopal, Sudarshan (Biomolecules, 2020-12-23)The vascular endothelium is the innermost layer of blood vessels and is a key regulator of vascular tone. Endothelial function is controlled by receptor signaling through G protein-coupled receptors, receptor tyrosine kinases ...
Oppermann, M; Diversé-Pierluissi, M; Drazner, MH; Dyer, SL; Freedman, NJ; Peppel, KC; Lefkowitz, RJ (Proc Natl Acad Sci U S A, 1996-07-23)Guanine nucleotide-binding regulatory protein (G protein)-coupled receptor kinases (GRKs) constitute a family of serine/threonine kinases that play a major role in the agonist-induced phosphorylation and desensitization ...