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cDNA for the human beta 2-adrenergic receptor: a protein with multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor.

dc.contributor.author Bolanowski, MA
dc.contributor.author Caron, MG
dc.contributor.author Dixon, RA
dc.contributor.author Dohlman, HG
dc.contributor.author Francke, U
dc.contributor.author Frielle, T
dc.contributor.author Kobilka, BK
dc.contributor.author Lefkowitz, Robert J
dc.contributor.author Sigal, IS
dc.contributor.author Yang-Feng, TL
dc.coverage.spatial United States
dc.date.accessioned 2013-09-24T18:04:27Z
dc.date.issued 1987-01
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/3025863
dc.identifier.issn 0027-8424
dc.identifier.uri https://hdl.handle.net/10161/7876
dc.description.abstract We have isolated and sequenced a cDNA encoding the human beta 2-adrenergic receptor. The deduced amino acid sequence (413 residues) is that of a protein containing seven clusters of hydrophobic amino acids suggestive of membrane-spanning domains. While the protein is 87% identical overall with the previously cloned hamster beta 2-adrenergic receptor, the most highly conserved regions are the putative transmembrane helices (95% identical) and cytoplasmic loops (93% identical), suggesting that these regions of the molecule harbor important functional domains. Several of the transmembrane helices also share lesser degrees of identity with comparable regions of select members of the opsin family of visual pigments. We have localized the gene for the beta 2-adrenergic receptor to q31-q32 on chromosome 5. This is the same position recently determined for the gene encoding the receptor for platelet-derived growth factor and is adjacent to that for the FMS protooncogene, which encodes the receptor for the macrophage colony-stimulating factor.
dc.language eng
dc.relation.ispartof Proc Natl Acad Sci U S A
dc.subject Amino Acid Sequence
dc.subject Animals
dc.subject Base Sequence
dc.subject Cell Membrane
dc.subject Chromosome Mapping
dc.subject Chromosomes, Human, Pair 14
dc.subject Cricetinae
dc.subject Cricetulus
dc.subject DNA
dc.subject Female
dc.subject Humans
dc.subject Hybrid Cells
dc.subject Placenta
dc.subject Platelet-Derived Growth Factor
dc.subject Pregnancy
dc.subject Protein Conformation
dc.subject Receptors, Adrenergic, beta
dc.title cDNA for the human beta 2-adrenergic receptor: a protein with multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor.
dc.type Journal article
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/3025863
pubs.begin-page 46
pubs.end-page 50
pubs.issue 1
pubs.organisational-group Basic Science Departments
pubs.organisational-group Biochemistry
pubs.organisational-group Cell Biology
pubs.organisational-group Chemistry
pubs.organisational-group Clinical Science Departments
pubs.organisational-group Duke
pubs.organisational-group Duke Cancer Institute
pubs.organisational-group Duke Institute for Brain Sciences
pubs.organisational-group Institutes and Centers
pubs.organisational-group Institutes and Provost's Academic Units
pubs.organisational-group Medicine
pubs.organisational-group Medicine, Cardiology
pubs.organisational-group Neurobiology
pubs.organisational-group Pathology
pubs.organisational-group School of Medicine
pubs.organisational-group Trinity College of Arts & Sciences
pubs.organisational-group University Institutes and Centers
pubs.publication-status Published
pubs.volume 84


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