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<p>This dissertation is concerned with the relationships between experiments in literature,
science, and politics in twentieth-century United States culture. I argue that the
three can be considered together by understanding "experimentation" as a set of processes
rather than a method, and highlighting the centrality of writing and reading to experiments
in all three arenas. Drawing on scientist Ludwik Fleck's concept of "valuable experiments,"
I read specific experiments in each field in conversation with the others, highlighting
the ways in which science and politics require aesthetic structures, the ways in which
science and literature reconfigure politics, and the ways in which politics and literature
can intervene in and reconfigure scientific practices. Ultimately, I try to develop
a reading practice that can make visible the shared transformative capacities of science,
literature, and radical politics.</p><p>In the course of three chapters, I analyze
the formal and conceptual innovations of writers such as William Burroughs, Ralph
Ellison, and Carson McCullers, who were intimately affected by the uses of experimental
science in corrective institutional practice. In doing so, I develop a concept of
"experimental literature" that is distinct from avant-garde literature and can account
for the investments that these writers share with scientists such as Albert Hofmann,
Albert Einstein, and Margaret Mead. I argue that experimental writers denature literary
genres that depend on coherent subjects, transparent reality, and developmental progress
in order to disrupt similar assumptions that underpin positivist science. By understanding
valuable experimental science and writing as continuous challenges to standardized
scientific knowledge, I show how these writers contribute to ongoing radical social
projects of queer and black radical traditions--such as those of George Jackson and
the Combahee River Collective--which are grounded in knowledge as an aesthetic and
political practice.</p>
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