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Cysteine proteinase-1 and cut protein isoform control dendritic innervation of two distinct sensory fields by a single neuron.

dc.contributor.author Lyons, Gray R
dc.contributor.author Andersen, Ryan O
dc.contributor.author Abdi, Khadar
dc.contributor.author Song, Won-Seok
dc.contributor.author Kuo, Chay T
dc.coverage.spatial United States
dc.date.accessioned 2014-02-27T17:07:20Z
dc.date.issued 2014-03-13
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/24582961
dc.identifier S2211-1247(14)00082-5
dc.identifier.uri https://hdl.handle.net/10161/8375
dc.description.abstract Dendrites often exhibit structural changes in response to local inputs. Although mechanisms that pattern and maintain dendritic arbors are becoming clearer, processes regulating regrowth, during context-dependent plasticity or after injury, remain poorly understood. We found that a class of Drosophila sensory neurons, through complete pruning and regeneration, can elaborate two distinct dendritic trees, innervating independent sensory fields. An expression screen identified Cysteine proteinase-1 (Cp1) as a critical regulator of this process. Unlike known ecdysone effectors, Cp1-mutant ddaC neurons pruned larval dendrites normally but failed to regrow adult dendrites. Cp1 expression was upregulated/concentrated in the nucleus during metamorphosis, controlling production of a truncated Cut homeodomain transcription factor. This truncated Cut, but not the full-length protein, allowed Cp1-mutant ddaC neurons to regenerate higher-order adult dendrites. These results identify a molecular pathway needed for dendrite regrowth after pruning, which allows the same neuron to innervate distinct sensory fields.
dc.language eng
dc.publisher CELL PRESS
dc.relation.ispartof Cell Rep
dc.relation.isversionof 10.1016/j.celrep.2014.02.003
dc.subject Animals
dc.subject Cysteine Endopeptidases
dc.subject Dendrites
dc.subject Drosophila
dc.subject Drosophila Proteins
dc.subject Protein Isoforms
dc.subject Sensory Receptor Cells
dc.title Cysteine proteinase-1 and cut protein isoform control dendritic innervation of two distinct sensory fields by a single neuron.
dc.type Journal article
duke.contributor.id Kuo, Chay T|0445762
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/24582961
pubs.begin-page 783
pubs.end-page 791
pubs.issue 5
pubs.organisational-group Basic Science Departments
pubs.organisational-group Cell Biology
pubs.organisational-group Clinical Science Departments
pubs.organisational-group Duke
pubs.organisational-group Duke Cancer Institute
pubs.organisational-group Duke Institute for Brain Sciences
pubs.organisational-group Institutes and Centers
pubs.organisational-group Institutes and Provost's Academic Units
pubs.organisational-group Neurobiology
pubs.organisational-group Pediatrics
pubs.organisational-group Pediatrics, Neonatology
pubs.organisational-group School of Medicine
pubs.organisational-group University Institutes and Centers
pubs.publication-status Published
pubs.volume 6
dc.identifier.eissn 2211-1247


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