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Across the meiotic divide - CSF activity in the post-Emi2/XErp1 era.

dc.contributor.author Wu, JQ
dc.contributor.author Kornbluth, S
dc.coverage.spatial England
dc.date.accessioned 2014-03-06T18:11:51Z
dc.date.issued 2008-11-01
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/18946022
dc.identifier 121/21/3509
dc.identifier.issn 0021-9533
dc.identifier.uri http://hdl.handle.net/10161/8390
dc.description.abstract Vertebrate eggs are arrested at the metaphase stage of meiosis II. Only upon fertilization will the metaphase-II-arrested eggs exit meiosis II and enter interphase. In 1971, Masui and Markert injected egg extracts into a two-cell-stage embryo and found that the injected blastomere arrested at the next mitosis. On the basis of these observations, they proposed the existence of an activity present in the eggs that is responsible for meiosis-II arrest and can induce mitotic arrest, and named this activity cytostatic factor (CSF). Although the existence of CSF was hypothesized more than 35 years ago, its precise identity remained unclear until recently. The discovery of the Mos-MAPK pathway and characterization of the anaphase-promoting complex/cyclosome (APC/C) as a central regulator of M-phase exit provided the framework for a molecular understanding of CSF. These pathways have now been linked by the discovery and characterization of the protein Emi2, a meiotic APC/C inhibitor, the activity and stability of which are controlled by the Mos-MAPK pathway. Continued investigation into the mechanism of action and mode of regulation of Emi2 promises to shed light not only on CSF function, but also on the general principles of APC/C regulation and the control of protein function by MAPK pathways.
dc.language eng
dc.relation.ispartof J Cell Sci
dc.relation.isversionof 10.1242/jcs.036855
dc.subject Animals
dc.subject Cyclin B
dc.subject Developmental Biology
dc.subject F-Box Proteins
dc.subject Feedback, Physiological
dc.subject Gene Expression Regulation, Developmental
dc.subject MAP Kinase Signaling System
dc.subject Meiosis
dc.subject Mitosis
dc.subject Models, Biological
dc.subject Oocytes
dc.subject Phosphorylation
dc.subject Proto-Oncogene Proteins c-mos
dc.subject Xenopus Proteins
dc.title Across the meiotic divide - CSF activity in the post-Emi2/XErp1 era.
dc.type Journal article
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/18946022
pubs.begin-page 3509
pubs.end-page 3514
pubs.issue Pt 21
pubs.organisational-group Basic Science Departments
pubs.organisational-group Duke
pubs.organisational-group Duke Cancer Institute
pubs.organisational-group Institutes and Centers
pubs.organisational-group Pharmacology & Cancer Biology
pubs.organisational-group School of Medicine
pubs.publication-status Published
pubs.volume 121


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