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Apoptosis in Drosophila: neither fish nor fowl (nor man, nor worm).

dc.contributor.author Kornbluth, S
dc.contributor.author White, K
dc.coverage.spatial England
dc.date.accessioned 2014-03-13T16:32:11Z
dc.date.issued 2005-05-01
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/15860727
dc.identifier 118/9/1779
dc.identifier.issn 0021-9533
dc.identifier.uri https://hdl.handle.net/10161/8399
dc.description.abstract Studies in a wide variety of organisms have produced a general model for the induction of apoptosis in which multiple signaling pathways lead ultimately to activation of the caspase family of proteases. Once activated, these enzymes cleave key cellular substrates to promote the orderly dismantling of dying cells. A broad similarity exists in the cell death pathways operating in different organisms and there is a clear evolutionary conservation of apoptotic regulators such as caspases, Bcl-2 family members, inhibitor of apoptosis (IAP) proteins, IAP antagonists and caspase activators. Despite this, studies in Caenorhabditis elegans, Drosophila and vertebrates have revealed some apparent differences both in the way apoptosis is regulated and in the way individual molecules contribute to the propagation of the death signal. For example, whereas cytochrome c released from mitochondria clearly promotes caspase activation in vertebrates, there is no documented role for cytochrome c in C. elegans apoptosis and its role in Drosophila is highly controversial. In addition, the apoptotic potency of IAP antagonists appears to be greater in Drosophila than in vertebrates, indicating that IAPs may be of different relative importance in different organisms. Thus, although Drosophila, worms and humans share a host of apoptotic regulators, the way in which they function may not be identical.
dc.language eng
dc.relation.ispartof J Cell Sci
dc.relation.isversionof 10.1242/jcs.02377
dc.subject Animals
dc.subject Apoptosis
dc.subject Caspases
dc.subject Cytochromes c
dc.subject Drosophila melanogaster
dc.subject Enzyme Inhibitors
dc.subject Humans
dc.subject Models, Biological
dc.subject Proto-Oncogene Proteins c-bcl-2
dc.title Apoptosis in Drosophila: neither fish nor fowl (nor man, nor worm).
dc.type Journal article
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/15860727
pubs.begin-page 1779
pubs.end-page 1787
pubs.issue Pt 9
pubs.organisational-group Basic Science Departments
pubs.organisational-group Duke
pubs.organisational-group Duke Cancer Institute
pubs.organisational-group Institutes and Centers
pubs.organisational-group Pharmacology & Cancer Biology
pubs.organisational-group School of Medicine
pubs.publication-status Published
pubs.volume 118


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