dc.contributor.author |
Kornbluth, Sally |
|
dc.contributor.author |
White, Kristin |
|
dc.coverage.spatial |
England |
|
dc.date.accessioned |
2014-03-13T16:32:11Z |
|
dc.date.issued |
2005-05-01 |
|
dc.identifier |
http://www.ncbi.nlm.nih.gov/pubmed/15860727 |
|
dc.identifier |
118/9/1779 |
|
dc.identifier.issn |
0021-9533 |
|
dc.identifier.uri |
https://hdl.handle.net/10161/8399 |
|
dc.description.abstract |
Studies in a wide variety of organisms have produced a general model for the induction
of apoptosis in which multiple signaling pathways lead ultimately to activation of
the caspase family of proteases. Once activated, these enzymes cleave key cellular
substrates to promote the orderly dismantling of dying cells. A broad similarity exists
in the cell death pathways operating in different organisms and there is a clear evolutionary
conservation of apoptotic regulators such as caspases, Bcl-2 family members, inhibitor
of apoptosis (IAP) proteins, IAP antagonists and caspase activators. Despite this,
studies in Caenorhabditis elegans, Drosophila and vertebrates have revealed some apparent
differences both in the way apoptosis is regulated and in the way individual molecules
contribute to the propagation of the death signal. For example, whereas cytochrome
c released from mitochondria clearly promotes caspase activation in vertebrates, there
is no documented role for cytochrome c in C. elegans apoptosis and its role in Drosophila
is highly controversial. In addition, the apoptotic potency of IAP antagonists appears
to be greater in Drosophila than in vertebrates, indicating that IAPs may be of different
relative importance in different organisms. Thus, although Drosophila, worms and humans
share a host of apoptotic regulators, the way in which they function may not be identical.
|
|
dc.language |
eng |
|
dc.publisher |
The Company of Biologists |
|
dc.relation.ispartof |
J Cell Sci |
|
dc.relation.isversionof |
10.1242/jcs.02377 |
|
dc.subject |
Animals |
|
dc.subject |
Apoptosis |
|
dc.subject |
Caspases |
|
dc.subject |
Cytochromes c |
|
dc.subject |
Drosophila melanogaster |
|
dc.subject |
Enzyme Inhibitors |
|
dc.subject |
Humans |
|
dc.subject |
Models, Biological |
|
dc.subject |
Proto-Oncogene Proteins c-bcl-2 |
|
dc.title |
Apoptosis in Drosophila: neither fish nor fowl (nor man, nor worm). |
|
dc.type |
Journal article |
|
duke.contributor.id |
Kornbluth, Sally|0098545 |
|
pubs.author-url |
http://www.ncbi.nlm.nih.gov/pubmed/15860727 |
|
pubs.begin-page |
1779 |
|
pubs.end-page |
1787 |
|
pubs.issue |
Pt 9 |
|
pubs.organisational-group |
Basic Science Departments |
|
pubs.organisational-group |
Duke |
|
pubs.organisational-group |
Duke Cancer Institute |
|
pubs.organisational-group |
Institutes and Centers |
|
pubs.organisational-group |
Pharmacology & Cancer Biology |
|
pubs.organisational-group |
School of Medicine |
|
pubs.publication-status |
Published |
|
pubs.volume |
118 |
|