Improving the lens design and performance of a contemporary electromagnetic shock wave lithotripter.
Repository Usage Stats
The efficiency of shock wave lithotripsy (SWL), a noninvasive first-line therapy for millions of nephrolithiasis patients, has not improved substantially in the past two decades, especially in regard to stone clearance. Here, we report a new acoustic lens design for a contemporary electromagnetic (EM) shock wave lithotripter, based on recently acquired knowledge of the key lithotripter field characteristics that correlate with efficient and safe SWL. The new lens design addresses concomitantly three fundamental drawbacks in EM lithotripters, namely, narrow focal width, nonidealized pulse profile, and significant misalignment in acoustic focus and cavitation activities with the target stone at high output settings. Key design features and performance of the new lens were evaluated using model calculations and experimental measurements against the original lens under comparable acoustic pulse energy (E+) of 40 mJ. The -6-dB focal width of the new lens was enhanced from 7.4 to 11 mm at this energy level, and peak pressure (41 MPa) and maximum cavitation activity were both realigned to be within 5 mm of the lithotripter focus. Stone comminution produced by the new lens was either statistically improved or similar to that of the original lens under various in vitro test conditions and was significantly improved in vivo in a swine model (89% vs. 54%, P = 0.01), and tissue injury was minimal using a clinical treatment protocol. The general principle and associated techniques described in this work can be applied to design improvement of all EM lithotripters.
Published Version (Please cite this version)10.1073/pnas.1319203111
Publication InfoNeisius, Andreas; Smith, Nathan B; Sankin, Georgy; Kuntz, Nicholas John; Madden, John Francis; Fovargue, Daniel E; ... Zhong, Pei (2014). Improving the lens design and performance of a contemporary electromagnetic shock wave lithotripter. Proc Natl Acad Sci U S A, 111(13). pp. E1167-E1175. 10.1073/pnas.1319203111. Retrieved from https://hdl.handle.net/10161/8403.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
More InfoShow full item record
Associate Professor of Surgery
Associate Professor of Pathology
James F. Glenn, M.D. Distinguished Professor of Urology
1. Minimally invasive management of urologic diseases 2. Minimally invasive management of renal and ureteral stones 3. Medical management of nephrolithiasis 4. Bioeffects of shock wave lithotripsy 5. Basic physics of shock wave lithotripsy 6. Intracorporeal lithotripsy for stone fragmentation 7. Minimally invasive management of urinary tract obstruction, including ureteropelvic junction obstruction and ureteral strictures 8. Enhanced imaging modalities f
Gendell Family Professor of the Practice
Professor in the Department of Mechanical Engineering and Materials Science
My research focuses on four broad and interconnected areas in the emerging field of therapeutic ultrasound, which is located at the interface of engineering, biology and clinical medicine. Current research interests in my group include: Ultrasound-targeted gene delivery and activation Synergistic combination of high-intensity focused ultrasound (HIFU) and immunotherapy for cancer treatment Innovations in shock wave lithotripsy (SWL) technology</l
Alphabetical list of authors with Scholars@Duke profiles.