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The influence of hepatic function on prostate cancer outcomes after radical prostatectomy.

dc.contributor.author Bañez, LL
dc.contributor.author Loftis, RM
dc.contributor.author Freedland, SJ
dc.contributor.author Presti, JC
dc.contributor.author Aronson, WJ
dc.contributor.author Amling, CL
dc.contributor.author Kane, CJ
dc.contributor.author Terris, MK
dc.coverage.spatial England
dc.date.accessioned 2014-05-06T14:14:54Z
dc.date.issued 2010-06
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/20195294
dc.identifier pcan20103
dc.identifier.uri http://hdl.handle.net/10161/8619
dc.description.abstract Prostate growth is dependent on circulating androgens, which can be influenced by hepatic function. Liver disease has been suggested to influence prostate cancer (CaP) incidence. However, the effect of hepatic function on CaP outcomes has not been investigated. A total of 1181 patients who underwent radical prostatectomy (RP) between 1988 and 2008 at four Veterans Affairs hospitals that comprise the Shared Equal Access Regional Cancer Hospital database and had available liver function test (LFT) data were included in the study. Independent associations of LFTs with unfavorable pathological features and biochemical recurrence were determined using logistic and Cox regression analyses. Serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT) levels were elevated in 8.2 and 4.4% of patients, respectively. After controlling for CaP features, logistic regression revealed a significant association between SGOT levels and pathological Gleason sum > or =7(4+3) cancer (odds ratio=2.12; 95% confidence interval=1.11-4.05; P=0.02). Mild hepatic dysfunction was significantly associated with adverse CaP grade, but was not significantly associated with other adverse pathological features or biochemical recurrence in a cohort of men undergoing RP. The effect of moderate-to-severe liver disease on disease outcomes in CaP patients managed non-surgically remains to be investigated.
dc.language eng
dc.relation.ispartof Prostate Cancer Prostatic Dis
dc.relation.isversionof 10.1038/pcan.2010.3
dc.subject Alanine Transaminase
dc.subject Aspartate Aminotransferases
dc.subject Humans
dc.subject Liver
dc.subject Liver Diseases
dc.subject Liver Function Tests
dc.subject Male
dc.subject Middle Aged
dc.subject Neoplasm Recurrence, Local
dc.subject Prostatectomy
dc.subject Prostatic Neoplasms
dc.subject Risk
dc.subject Treatment Outcome
dc.title The influence of hepatic function on prostate cancer outcomes after radical prostatectomy.
dc.type Journal article
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/20195294
pubs.begin-page 173
pubs.end-page 177
pubs.issue 2
pubs.organisational-group Duke
pubs.organisational-group Staff
pubs.publication-status Published
pubs.volume 13
dc.identifier.eissn 1476-5608


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