Magnetophoretic circuits for digital control of single particles and cells.
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The ability to manipulate small fluid droplets, colloidal particles and single cells with the precision and parallelization of modern-day computer hardware has profound applications for biochemical detection, gene sequencing, chemical synthesis and highly parallel analysis of single cells. Drawing inspiration from general circuit theory and magnetic bubble technology, here we demonstrate a class of integrated circuits for executing sequential and parallel, timed operations on an ensemble of single particles and cells. The integrated circuits are constructed from lithographically defined, overlaid patterns of magnetic film and current lines. The magnetic patterns passively control particles similar to electrical conductors, diodes and capacitors. The current lines actively switch particles between different tracks similar to gated electrical transistors. When combined into arrays and driven by a rotating magnetic field clock, these integrated circuits have general multiplexing properties and enable the precise control of magnetizable objects.
Published Version (Please cite this version)10.1038/ncomms4846
Publication InfoAbedini-Nassab, R; Hu, X; Jadhav, M; Kim, C; Kim, K; Lim, B; ... Yellen, Benjamin (2014). Magnetophoretic circuits for digital control of single particles and cells. Nat Commun, 5. pp. 3846. 10.1038/ncomms4846. Retrieved from https://hdl.handle.net/10161/8867.
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Associate Professor in the Department of Mechanical Engineering and Materials Science
Yellen's group is interested in developing highly parallel mechanisms for controlling the transport and assembly of ensembles of objects ranging from micron-sized colloidal particles to single cells. As of 2013, Professor Yellen is active in two main areas of research:1) Development of single cell analysis tools using magnetic circuits. The goal of this project is to develop an automated single cell analysis platform that allows for highly flexible and highly paralle