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Magnetophoretic circuits for digital control of single particles and cells.

dc.contributor.author Abedini-Nassab, R
dc.contributor.author Hu, X
dc.contributor.author Jadhav, M
dc.contributor.author Kim, C
dc.contributor.author Kim, K
dc.contributor.author Lim, B
dc.contributor.author Lim, YT
dc.contributor.author Noh, YW
dc.contributor.author Reddy, V
dc.contributor.author Yellen, Benjamin
dc.coverage.spatial England
dc.date.accessioned 2014-05-15T17:50:09Z
dc.date.issued 2014-05-14
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/24828763
dc.identifier ncomms4846
dc.identifier.uri https://hdl.handle.net/10161/8867
dc.description.abstract The ability to manipulate small fluid droplets, colloidal particles and single cells with the precision and parallelization of modern-day computer hardware has profound applications for biochemical detection, gene sequencing, chemical synthesis and highly parallel analysis of single cells. Drawing inspiration from general circuit theory and magnetic bubble technology, here we demonstrate a class of integrated circuits for executing sequential and parallel, timed operations on an ensemble of single particles and cells. The integrated circuits are constructed from lithographically defined, overlaid patterns of magnetic film and current lines. The magnetic patterns passively control particles similar to electrical conductors, diodes and capacitors. The current lines actively switch particles between different tracks similar to gated electrical transistors. When combined into arrays and driven by a rotating magnetic field clock, these integrated circuits have general multiplexing properties and enable the precise control of magnetizable objects.
dc.language eng
dc.relation.ispartof Nat Commun
dc.relation.isversionof 10.1038/ncomms4846
dc.subject Colloids
dc.subject Computers
dc.subject Hydrodynamics
dc.subject Magnets
dc.subject Nanoparticles
dc.subject Single-Cell Analysis
dc.title Magnetophoretic circuits for digital control of single particles and cells.
dc.type Journal article
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/24828763
pubs.begin-page 3846
pubs.organisational-group Biomedical Engineering
pubs.organisational-group Duke
pubs.organisational-group Mechanical Engineering and Materials Science
pubs.organisational-group Pratt School of Engineering
pubs.publication-status Published online
pubs.volume 5
dc.identifier.eissn 2041-1723


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