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The role of extracellular matrix elasticity and composition in regulating the nucleus pulposus cell phenotype in the intervertebral disc: a narrative review.

dc.contributor.author Hwang, Priscilla Y
dc.contributor.author Chen, Jun
dc.contributor.author Jing, Liufang
dc.contributor.author Hoffman, Brenton D
dc.contributor.author Setton, Lori A
dc.coverage.spatial United States
dc.date.accessioned 2014-05-23T14:35:55Z
dc.date.issued 2014-02
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/24390195
dc.identifier 1812596
dc.identifier.uri https://hdl.handle.net/10161/8879
dc.description.abstract Intervertebral disc (IVD) disorders are a major contributor to disability and societal health care costs. Nucleus pulposus (NP) cells of the IVD exhibit changes in both phenotype and morphology with aging-related IVD degeneration that may impact the onset and progression of IVD pathology. Studies have demonstrated that immature NP cell interactions with their extracellular matrix (ECM) may be key regulators of cellular phenotype, metabolism and morphology. The objective of this article is to review our recent experience with studies of NP cell-ECM interactions that reveal how ECM cues can be manipulated to promote an immature NP cell phenotype and morphology. Findings demonstrate the importance of a soft (<700 Pa), laminin-containing ECM in regulating healthy, immature NP cells. Knowledge of NP cell-ECM interactions can be used for development of tissue engineering or cell delivery strategies to treat IVD-related disorders.
dc.language eng
dc.publisher ASME International
dc.relation.ispartof J Biomech Eng
dc.relation.isversionof 10.1115/1.4026360
dc.subject Animals
dc.subject Cell Differentiation
dc.subject Computer Simulation
dc.subject Elastic Modulus
dc.subject Extracellular Matrix
dc.subject Fibrillar Collagens
dc.subject Fibrocartilage
dc.subject Humans
dc.subject Intervertebral Disc
dc.subject Mechanotransduction, Cellular
dc.subject Models, Biological
dc.subject Stress, Mechanical
dc.title The role of extracellular matrix elasticity and composition in regulating the nucleus pulposus cell phenotype in the intervertebral disc: a narrative review.
dc.type Journal article
duke.contributor.id Chen, Jun|0251573
duke.contributor.id Hoffman, Brenton D|0575083
duke.contributor.id Setton, Lori A|0117045
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/24390195
pubs.begin-page 021010
pubs.issue 2
pubs.organisational-group Basic Science Departments
pubs.organisational-group Biomedical Engineering
pubs.organisational-group Cell Biology
pubs.organisational-group Clinical Science Departments
pubs.organisational-group Duke
pubs.organisational-group Duke Institute for Brain Sciences
pubs.organisational-group Institutes and Provost's Academic Units
pubs.organisational-group Orthopaedics
pubs.organisational-group Pratt School of Engineering
pubs.organisational-group School of Medicine
pubs.organisational-group University Institutes and Centers
pubs.publication-status Published
pubs.volume 136
dc.identifier.eissn 1528-8951


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