Bayesian inference of the number of factors in gene-expression analysis: application to human virus challenge studies.
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BACKGROUND: Nonparametric Bayesian techniques have been developed recently to extend the sophistication of factor models, allowing one to infer the number of appropriate factors from the observed data. We consider such techniques for sparse factor analysis, with application to gene-expression data from three virus challenge studies. Particular attention is placed on employing the Beta Process (BP), the Indian Buffet Process (IBP), and related sparseness-promoting techniques to infer a proper number of factors. The posterior density function on the model parameters is computed using Gibbs sampling and variational Bayesian (VB) analysis. RESULTS: Time-evolving gene-expression data are considered for respiratory syncytial virus (RSV), Rhino virus, and influenza, using blood samples from healthy human subjects. These data were acquired in three challenge studies, each executed after receiving institutional review board (IRB) approval from Duke University. Comparisons are made between several alternative means of per-forming nonparametric factor analysis on these data, with comparisons as well to sparse-PCA and Penalized Matrix Decomposition (PMD), closely related non-Bayesian approaches. CONCLUSIONS: Applying the Beta Process to the factor scores, or to the singular values of a pseudo-SVD construction, the proposed algorithms infer the number of factors in gene-expression data. For real data the "true" number of factors is unknown; in our simulations we consider a range of noise variances, and the proposed Bayesian models inferred the number of factors accurately relative to other methods in the literature, such as sparse-PCA and PMD. We have also identified a "pan-viral" factor of importance for each of the three viruses considered in this study. We have identified a set of genes associated with this pan-viral factor, of interest for early detection of such viruses based upon the host response, as quantified via gene-expression data.
Gene Expression Profiling
Oligonucleotide Array Sequence Analysis
Respiratory Syncytial Viruses
Virus Physiological Phenomena
Published Version (Please cite this version)10.1186/1471-2105-11-552
Publication InfoCarin, Lawrence; Chen, B; Chen, M; Dunson, David B; Ginsburg, Geoffrey Steven; Hero, Alfred; ... Zaas, Aimee Kirsch (2010). Bayesian inference of the number of factors in gene-expression analysis: application to human virus challenge studies. BMC Bioinformatics, 11. pp. 552. 10.1186/1471-2105-11-552. Retrieved from https://hdl.handle.net/10161/8946.
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James L. Meriam Professor of Electrical and Computer Engineering
Lawrence Carin earned the BS, MS, and PhD degrees in electrical engineering at the University of Maryland, College Park, in 1985, 1986, and 1989, respectively. In 1989 he joined the Electrical Engineering Department at Polytechnic University (Brooklyn) as an Assistant Professor, and became an Associate Professor there in 1994. In September 1995 he joined the Electrical Engineering Department at Duke University, where he is now a Professor, and Vice Provost for Research. From 2003-2014 he held th
Arts and Sciences Professor of Statistical Science
Development of novel approaches for representing and analyzing complex data. A particular focus is on methods that incorporate geometric structure (both known and unknown) and on probabilistic approaches to characterize uncertainty. In addition, a big interest is in scalable algorithms and in developing approaches with provable guarantees.This fundamental work is directly motivated by applications in biomedical research, network data analysis, neuroscience, genomics, ecol
Professor of Medicine
Dr. Geoffrey S. Ginsburg's research interests are in the development of novel paradigms for developing and translating genomic information into medical practice and the integration of personalized medicine into health care.
Professor of Medicine
1. Emerging Infections 2. Global Health 3. Epidemiology of infectious diseases 4. Clinical microbiology and diagnostics 5. Bioterrorism Preparedness 6. Surveillance for communicable diseases 7. Antimicrobial resistance
Associate Professor of Medicine
Medical education Genomic applications for diagnosis of infectious diseases Genomic applications for prediction of infectious diseases
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