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An Experimental and Quantitative Analysis of E. coli Stress Response: Metabolic and Antibiotic Stressors

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Date
2014
Author
Jalli, Inderpreet Singh
Advisor
Nijhout, Frederik
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Abstract

A series of experiments and mathematical models explore the response of the bacteria <italic>E. coli</italic> to stressors. Experimentally, the effect of L-homocysteine, a non-protein amino acid, is explored, and via math models, the effect of trimethoprim, a common antibiotic, is also explored. Previous work on L-homocysteine labels it a stressor, and this assertion is refined via the presented work. A mathematical model that improves on a previous work published by Kwon et al. (2008) explores the response of <italic>E. coli</italic> to various supplementations of amino acids when exposed to trimethoprim. New methods of developing antibiotics and therapeutic drug treatments are also explored.

Type
Dissertation
Department
Biology
Subject
Biology
Antibiotics
Bacteria
Mathematical modeling
Networks
Stress
Permalink
https://hdl.handle.net/10161/9103
Citation
Jalli, Inderpreet Singh (2014). An Experimental and Quantitative Analysis of E. coli Stress Response: Metabolic and Antibiotic Stressors. Dissertation, Duke University. Retrieved from https://hdl.handle.net/10161/9103.
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This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 United States License.

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