| dc.description.abstract |
<p>Interdisciplinary investigation at the interface of chemistry, engineering and
medicine has triggered the development of self-assembled nanomaterials with novel
biomaterial and optical properties. Targeted near infrared (NIR) emissive polymersomes
can be used as agents of deep tissue fluorescent imaging and targeted drug delivery.
For the development of these agents, my approaches were modification of polymersome
surface with functional groups for protein conjugation, and optimization of NIR emissive
fluorophores enhancing their organization homogeneity as well as increasing dispersion
in polymersomes matrix. Results show successful protein conjugation to biodegradable
polymersomes and thus a step forward to apply polymersomes for in vivo imaging and
targeted drug delivery with low toxicity.</p>
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