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Irisin and FNDC5 in retrospect: An exercise hormone or a transmembrane receptor?

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Date
2013-10-01
Author
Erickson, Harold P
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Abstract
FNDC5 (fibronectin domain-containing [protein] 5) was initially discovered and characterized by two groups in 2002. In 2011 FNDC5 burst into prominence as the parent of irisin, a small protein containing the fibronectin type III domain. Irisin was proposed to be secreted by skeletal muscle cells in response to exercise, and to circulate to fat tissue where it induced a transition to brown fat. Since brown fat results in dissipation of energy, this pathway is of considerable interest for metabolism and obesity. Here I review the original discoveries of FNDC5 and the more recent discovery of irisin. I note in particular three problems in the characterization of irisin: the antibodies used to detect irisin in plasma lack validity; the recombinant protein used to demonstrate activity in cell culture was severely truncated; and the degree of shedding of soluble irisin from the cell surface has not been quantitated. The original discovery proposing that FNDC5 may be a transmembrane receptor may deserve a new look.
Type
Journal article
Subject
FNDC5
brown adipocyte
exercise
fibronectin
irisin
Permalink
https://hdl.handle.net/10161/9280
Published Version (Please cite this version)
10.4161/adip.26082
Publication Info
Erickson, Harold P (2013). Irisin and FNDC5 in retrospect: An exercise hormone or a transmembrane receptor?. Adipocyte, 2(4). pp. 289-293. 10.4161/adip.26082. Retrieved from https://hdl.handle.net/10161/9280.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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Scholars@Duke

Erickson

Harold Paul Erickson

James B. Duke Distinguished Professor Emeritus
Recent research has been on cytoskeleton (eukaryotes and bacteria); a skirmish to debunk the irisin story; a reinterpretation of proposed multivalent binders of the coronavirus spike protein. I have also published an ebook on "Principles of Protein-Protein Association" suitable for a course module or individual learning.
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