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Irisin and FNDC5 in retrospect: An exercise hormone or a transmembrane receptor?

dc.contributor.author Erickson, Harold Paul
dc.coverage.spatial United States
dc.date.accessioned 2014-12-01T19:59:00Z
dc.date.issued 2013-10-01
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/24052909
dc.identifier 2013ADIPOCYTE130R
dc.identifier.issn 2162-3945
dc.identifier.uri https://hdl.handle.net/10161/9280
dc.description.abstract FNDC5 (fibronectin domain-containing [protein] 5) was initially discovered and characterized by two groups in 2002. In 2011 FNDC5 burst into prominence as the parent of irisin, a small protein containing the fibronectin type III domain. Irisin was proposed to be secreted by skeletal muscle cells in response to exercise, and to circulate to fat tissue where it induced a transition to brown fat. Since brown fat results in dissipation of energy, this pathway is of considerable interest for metabolism and obesity. Here I review the original discoveries of FNDC5 and the more recent discovery of irisin. I note in particular three problems in the characterization of irisin: the antibodies used to detect irisin in plasma lack validity; the recombinant protein used to demonstrate activity in cell culture was severely truncated; and the degree of shedding of soluble irisin from the cell surface has not been quantitated. The original discovery proposing that FNDC5 may be a transmembrane receptor may deserve a new look.
dc.language eng
dc.relation.ispartof Adipocyte
dc.relation.isversionof 10.4161/adip.26082
dc.subject FNDC5
dc.subject brown adipocyte
dc.subject exercise
dc.subject fibronectin
dc.subject irisin
dc.title Irisin and FNDC5 in retrospect: An exercise hormone or a transmembrane receptor?
dc.type Journal article
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/24052909
pubs.begin-page 289
pubs.end-page 293
pubs.issue 4
pubs.organisational-group Basic Science Departments
pubs.organisational-group Biochemistry
pubs.organisational-group Cell Biology
pubs.organisational-group Duke
pubs.organisational-group Duke Cancer Institute
pubs.organisational-group Institutes and Centers
pubs.organisational-group School of Medicine
pubs.publication-status Published
pubs.volume 2


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