Dopamine receptors in a songbird brain.
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Dopamine is a key neuromodulatory transmitter in the brain. It acts through dopamine receptors to affect changes in neural activity, gene expression, and behavior. In songbirds, dopamine is released into the striatal song nucleus Area X, and the levels depend on social contexts of undirected and directed singing. This differential release is associated with differential expression of activity-dependent genes, such as egr1 (avian zenk), which in mammalian brain are modulated by dopamine receptors. Here we cloned from zebra finch brain cDNAs of all avian dopamine receptors: the D1 (D1A, D1B, D1D) and D2 (D2, D3, D4) families. Comparative sequence analyses of predicted proteins revealed expected phylogenetic relationships, in which the D1 family exists as single exon and the D2 family exists as spliced exon genes. In both zebra finch and chicken, the D1A, D1B, and D2 receptors were highly expressed in the striatum, the D1D and D3 throughout the pallium and within the mesopallium, respectively, and the D4 mainly in the cerebellum. Furthermore, within the zebra finch, all receptors, except for D4, showed differential expression in song nuclei relative to the surrounding regions and developmentally regulated expression that decreased for most receptors during the sensory acquisition and sensorimotor phases of song learning. Within Area X, half of the cells expressed both D1A and D2 receptors, and a higher proportion of the D1A-only-containing neurons expressed egr1 during undirected but not during directed singing. Our findings are consistent with hypotheses that dopamine receptors may be involved in song development and social context-dependent behaviors.
Receptors, Dopamine D1
Receptors, Dopamine D2
Receptors, Dopamine D3
Receptors, Dopamine D4
Receptors, Dopamine D5
Published Version (Please cite this version)10.1002/cne.22255
Publication InfoKubikova, Lubica; Wada, Kazuhiro; & Jarvis, Erich D (2010). Dopamine receptors in a songbird brain. J Comp Neurol, 518(6). pp. 741-769. 10.1002/cne.22255. Retrieved from https://hdl.handle.net/10161/9310.
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Adjunct Professor in the Dept. of Neurobiology
Dr. Jarvis' laboratory studies the neurobiology of vocal communication. Emphasis is placed on the molecular pathways involved in the perception and production of learned vocalizations. They use an integrative approach that combines behavioral, anatomical, electrophysiological and molecular biological techniques. The main animal model used is songbirds, one of the few vertebrate groups that evolved the ability to learn vocalizations. The generality of the discoveries is tested in other vocal
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Identification of dopamine receptors across the extant avian family tree and analysis with other clades uncovers a polyploid expansion among vertebrates. Haug-Baltzell, Asher; Jarvis, Erich D; McCarthy, Fiona M; Lyons, Eric (Front Neurosci, 2015)Dopamine is an important central nervous system transmitter that functions through two classes of receptors (D1 and D2) to influence a diverse range of biological processes in vertebrates. With roles in regulating neural ...
Wong, Chloe Chung Yi; Caspi, Avshalom; Williams, Benjamin; Craig, Ian W; Houts, Renate; Ambler, Antony; Moffitt, Terrie E; ... (8 authors) (Epigenetics, 2010-08-16)DNA methylation is a key epigenetic mechanism involved in the developmental regulation of gene expression. Alterations in DNA methylation are established contributors to inter-individual phenotypic variation and have been ...
Sasaki, Aya; Sotnikova, Tatyana D; Gainetdinov, Raul R; Jarvis, Erich D (J Neurosci, 2006-08-30)Like the mammalian striatum, the songbird striatum receives dense dopaminergic input from the midbrain ventral tegmental area-substantia nigra pars compacta complex. The songbird striatum also contains a unique vocal nucleus, ...