Chromatin: bind at your own RSC.
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Recent work has identified a novel RSC-nucleosome complex that both strongly phases flanking nucleosomes and presents regulatory sites for ready access. These results challenge several widely held views.
Gene Expression Regulation, Fungal
Promoter Regions, Genetic
Saccharomyces cerevisiae Proteins
Published Version (Please cite this version)10.1016/j.cub.2011.01.060
Publication InfoBuchler, Nicolas E; & Bai, Lu (2011). Chromatin: bind at your own RSC. Curr Biol, 21(6). pp. R223-R225. 10.1016/j.cub.2011.01.060. Retrieved from https://hdl.handle.net/10161/9351.
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Assistant Professor of Biology
Our lab is interested in the systems biology and evolution of epigenetic switches (bistability) and clocks (oscillators) in gene regulatory networks, two functions that are essential for patterning, cell proliferation, and differentiation in biological systems. We also study biochemical oscillators such as the cell cycle, metabolic rhythms, and circadian clocks, which co-exist in the same cells and interact with one another through shared resources.