Can Genetics Predict Response to Complex Behavioral Interventions? Evidence from a Genetic Analysis of the Fast Track Randomized Control Trial.
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Early interventions are a preferred method for addressing behavioral problems in high-risk children, but often have only modest effects. Identifying sources of variation in intervention effects can suggest means to improve efficiency. One potential source of such variation is the genome. We conducted a genetic analysis of the Fast Track randomized control trial, a 10-year-long intervention to prevent high-risk kindergarteners from developing adult externalizing problems including substance abuse and antisocial behavior. We tested whether variants of the glucocorticoid receptor gene NR3C1 were associated with differences in response to the Fast Track intervention. We found that in European-American children, a variant of NR3C1 identified by the single-nucleotide polymorphism rs10482672 was associated with increased risk for externalizing psychopathology in control group children and decreased risk for externalizing psychopathology in intervention group children. Variation in NR3C1 measured in this study was not associated with differential intervention response in African-American children. We discuss implications for efforts to prevent externalizing problems in high-risk children and for public policy in the genomic era.
Antisocial Personality Disorder
Child Behavior Disorders
Early Medical Intervention
Polymorphism, Single Nucleotide
Randomized Controlled Trials as Topic
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Assistant Professor in Population Health Sciences
The goal of Dan’s work is to reduce social inequalities in aging outcomes in the US and elsewhere. Dan's research seeks to understand how genes and environments combine to shape health across the life course. His work uses tools from genome science and longitudinal data from population-based cohort studies. The aim is to identify targets for policy and clinical interventions to promote positive development in early life and extend healthspan.Areas of interest: Aging, health
Pritzker Professor of Early Learning Policy Studies
Kenneth A. Dodge is the Pritzker Professor of Public Policy and Professor of Psychology and Neuroscience at Duke University. He is also the founding and past director of the Center for Child and Family Policy. He is a leading scholar in the development and prevention of aggressive and violent behaviors. His work provides a model for understanding how some young children grow up to engage in aggression and violence and provides a fram
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