Simultaneous transcranial magnetic stimulation and single-neuron recording in alert non-human primates.
Abstract
Transcranial magnetic stimulation (TMS) is a widely used, noninvasive method for stimulating
nervous tissue, yet its mechanisms of effect are poorly understood. Here we report
new methods for studying the influence of TMS on single neurons in the brain of alert
non-human primates. We designed a TMS coil that focuses its effect near the tip of
a recording electrode and recording electronics that enable direct acquisition of
neuronal signals at the site of peak stimulus strength minimally perturbed by stimulation
artifact in awake monkeys (Macaca mulatta). We recorded action potentials within ∼1
ms after 0.4-ms TMS pulses and observed changes in activity that differed significantly
for active stimulation as compared with sham stimulation. This methodology is compatible
with standard equipment in primate laboratories, allowing easy implementation. Application
of these tools will facilitate the refinement of next generation TMS devices, experiments
and treatment protocols.
Type
Journal articleSubject
Action PotentialsAnimals
Artifacts
Electrodes
Equipment Design
Female
Macaca mulatta
Male
Neurons
Patch-Clamp Techniques
Prefrontal Cortex
Transcranial Magnetic Stimulation
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https://hdl.handle.net/10161/9482Published Version (Please cite this version)
10.1038/nn.3751Publication Info
(2014). Simultaneous transcranial magnetic stimulation and single-neuron recording in alert
non-human primates. Nat Neurosci, 17(8). pp. 1130-1136. 10.1038/nn.3751. Retrieved from https://hdl.handle.net/10161/9482.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
Tobias Egner
Professor of Psychology and Neuroscience
My goal is to understand how humans produce purposeful, adaptive behavior. The main
ingredient for adaptive behavior, in all animals, is memory: we understand the world
around us by matching the flow of incoming sensory information to previous experience.
Importantly, by retrieving past episodes that resemble our present situation, we can
predict what is likely to happen next, thus anticipating forthcoming stimuli and advantageous
responses learned from past outcomes. Hence, I am interested i
Angel Vladimirov Peterchev
Associate Professor in Psychiatry and Behavioral Sciences
I direct the Brain Stimulation Engineering Lab (BSEL) which focuses on the development
and modeling of devices and application paradigms for transcranial brain stimulation.
Transcranial brain stimulation involves non-invasive delivery of fields (e.g., electric
and magnetic) to the brain that modulate neural activity. Transcranial brain stimulation
is increasingly used as a tool for brain research and a therapeutic intervention in
neurology and psychiatry. My lab works closely with neuroscientist
Marc A. Sommer
W. H. Gardner, Jr. Associate Professor
We study circuits for cognition. Using a combination of neurophysiology and biomedical
engineering, we focus on the interaction between brain areas during visual perception,
decision-making, and motor planning. Specific projects include the role of frontal
cortex in metacognition, the role of cerebellar-frontal circuits in action timing,
the neural basis of "good enough" decision-making (satisficing), and the neural mechanisms
of transcranial magnetic stimulation (TMS).
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