Simultaneous transcranial magnetic stimulation and single-neuron recording in alert non-human primates.
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Transcranial magnetic stimulation (TMS) is a widely used, noninvasive method for stimulating nervous tissue, yet its mechanisms of effect are poorly understood. Here we report new methods for studying the influence of TMS on single neurons in the brain of alert non-human primates. We designed a TMS coil that focuses its effect near the tip of a recording electrode and recording electronics that enable direct acquisition of neuronal signals at the site of peak stimulus strength minimally perturbed by stimulation artifact in awake monkeys (Macaca mulatta). We recorded action potentials within ∼1 ms after 0.4-ms TMS pulses and observed changes in activity that differed significantly for active stimulation as compared with sham stimulation. This methodology is compatible with standard equipment in primate laboratories, allowing easy implementation. Application of these tools will facilitate the refinement of next generation TMS devices, experiments and treatment protocols.
Transcranial Magnetic Stimulation
Published Version (Please cite this version)10.1038/nn.3751
Publication InfoMueller, Jerel K; Grigsby, Erinn M; Prevosto, Vincent; Petraglia, Frank W; Rao, Hrishikesh; Deng, Zhi-De; ... Grill, Warren M (2014). Simultaneous transcranial magnetic stimulation and single-neuron recording in alert non-human primates. Nat Neurosci, 17(8). pp. 1130-1136. 10.1038/nn.3751. Retrieved from https://hdl.handle.net/10161/9482.
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Professor of Psychology and Neuroscience
My goal is to understand how humans produce purposeful, adaptive behavior. The main ingredient for adaptive behavior, in all animals, is memory: we understand the world around us by matching the flow of incoming sensory information to previous experience. Importantly, by retrieving past episodes that resemble our present situation, we can predict what is likely to happen next, thus anticipating forthcoming stimuli and advantageous responses learned from past outcomes. Hence, I am interested i
Edmund T. Pratt, Jr. School Distinguished Professor of Biomedical Engineering
Our research employs engineering approaches to understand and control neural function. We work on fundamental questions and applied development in electrical stimulation of the nervous system to restore function to individuals with neurological impairment or injury. Current projects include:• understanding the mechanisms of and developing advanced approaches to deep brain stimulation to treat movement disorders, • developing novel approaches to peripheral nerve e
Associate Professor in Psychiatry and Behavioral Sciences
I direct the Brain Stimulation Engineering Lab (BSEL) which focuses on the development and modeling of devices and application paradigms for transcranial brain stimulation. Transcranial brain stimulation involves non-invasive delivery of fields (e.g., electric and magnetic) to the brain that modulate neural activity. Transcranial brain stimulation is increasingly used as a tool for brain research and a therapeutic intervention in neurology and psychiatry. My lab works closely with neuroscientist
Adjunct Professor in the Department of Neurobiology
Our lab tries to understand how the brain makes decisions. We are particularly interested in the biological mechanisms that allow people and other animals to make decisions when the environment is ambiguous or complicated by the presence of other individuals. We use a broad array of techniques, including single neuron recordings, microstimulation, neuropharmacology, eye tracking, brain imaging, and genomics to answer these questions. Our work is motivated by ethology, evolutionary biology, and e
This author no longer has a Scholars@Duke profile, so the information shown here reflects their Duke status at the time this item was deposited.
W. H. Gardner, Jr. Associate Professor
We study circuits for cognition. Using a combination of neurophysiology and biomedical engineering, we focus on the interaction between brain areas during visual perception, decision-making, and motor planning. Specific projects include the role of frontal cortex in metacognition, the role of cerebellar-frontal circuits in action timing, the neural basis of "good enough" decision-making (satisficing), and the neural mechanisms of transcranial magnetic stimulation (TMS).
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